Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.39 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.39 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.37 |
| ▸ | CTRL | P40313 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.37 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665022 | 0.81 | CYP3A4 (0.42) | RENCACNA1BMMP1CYP3A4CYP3A5 | |
| SCHEMBL6473757 | 0.80 | CACNA1B (0.46) | RENCACNA1BMMP1CYP3A4CYP3A5 | |
| SCHEMBL7339983 | 0.70 | CTSS (0.59) | RENCACNA1BYAP1PSMB5CTSS | |
| SCHEMBL13296580 | 0.69 | MAPT (0.57) | MMP1POLBMAPTATMNPSR1 | |
| SCHEMBL7345553 | 0.69 | CACNA1B (0.47) | RENCACNA1BMMP1POLBMAPT | |
| SCHEMBL7345558 | 0.69 | CACNA1B (0.47) | RENCACNA1BMMP1POLBMAPT | |
| SCHEMBL21981114 | 0.68 | LY96 (0.53) | POLBMAPTNPSR1TDP1CTSS | |
| SCHEMBL6479130 | 0.68 | CTSK (0.55) | CACNA1BCTSS | |
| SCHEMBL7338655 | 0.68 | MMP1 (0.53) | RENCACNA1BMMP1PSMB5PSMB11 | |
| SCHEMBL7342868 | 0.68 | CTSL (0.47) | RENCACNA1BMMP1YAP1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |