Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.43 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.43 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.42 |
| ▸ | YAP1 | P46937 | 2/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.41 |
| ▸ | CTRL | P40313 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481358 | 0.86 | CACNA1B (0.49) | CACNA1BMMP1RAB9AYAP1PSMB8 | |
| SCHEMBL6686538 | 0.86 | CACNA1B (0.49) | CACNA1BMMP1RAB9AYAP1PSMB8 | |
| SCHEMBL6479130 | 0.85 | CTSK (0.55) | CACNA1BCTSS | |
| Hydrochloric Acid SCHEMBL6473882 | 0.85 | CACNA1B (0.48) | CACNA1BMMP1RAB9APSMB5YAP1 | |
| Hydrochloric Acid SCHEMBL7539648 | 0.85 | CACNA1B (0.48) | CACNA1BMMP1RAB9APSMB5YAP1 | |
| SCHEMBL6665022 | 0.80 | CYP3A4 (0.42) | CACNA1BMMP1CYP3A4CYP3A5CYP3A7 | |
| SCHEMBL6665016 | 0.80 | REN (0.41) | CACNA1BMMP1CYP3A4CYP3A5CYP3A7 | |
| SCHEMBL7339983 | 0.79 | CTSS (0.59) | CACNA1BCTSSPSMB5YAP1PSMB10 | |
| SCHEMBL6481485 | 0.77 | CTSK (0.56) | CTSS | |
| SCHEMBL6473778 | 0.77 | YAP1 (0.49) | PSMB5YAP1PSMB10PSMB2PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |