Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Inogatran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Inogatran SCHEMBL22745 | 0.99 | F2 (0.52) | F2PRSS1F10PLGPLAT | |
| Inogatran SCHEMBL1208039 | 0.99 | F2 (0.52) | F2PRSS1F10PLGPLAT | |
| Inogatran SCHEMBL22746 | 0.99 | F2 (0.52) | F2PRSS1F10PLGPLAT | |
| SCHEMBL8409263 | 0.86 | F2 (0.45) | F2PRSS1F10PLGPLAT | |
| Inogatran SCHEMBL871973 | 0.86 | F2 (0.47) | F2PRSS1F10PLGPLAT | |
| SCHEMBL6665350 | 0.83 | PRCP (0.45) | F2PRSS1F10PLG | |
| SCHEMBL14082058 | 0.80 | F2 (0.62) | F2PRSS1F10PLGPLAT | |
| SCHEMBL5862690 | 0.76 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL13141174 | 0.75 | F2 (0.39) | F2PRSS1F10PLGPLAT | |
| SCHEMBL23793969 | 0.75 | F2 (0.75) | F2PRSS1F10PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191932-B1 | PRODUCTION OF AGGLOMERATES OF INOGATRAN AND THE COMPOUND INOGATRAN ANHYDRATE | ASTRAZENECA AB (SE) | 2004-09-08 | — | — | EP | disclosed |
| US-20030134875-A1 | Production of agglomerates | ASTRAZENECA AB (SE) | 2003-07-17 | — | — | US | disclosed |
| US-6531490-B1 | Production of agglomerates of inogatran and the compound inogatran anhydrate | ASTRAZENECA AB (SE) | 2003-03-11 | — | — | US | disclosed |
| EP-1191932-A1 | PRODUCTION OF AGGLOMERATES OF INOGATRAN AND THE COMPOUND INOGATRAN ANHYDRATE | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076504-A1 | PRODUCTION OF AGGLOMERATES OF INOGATRAN AND THE COMPOUND INOGATRAN ANHYDRATE | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |