Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672052 | 0.82 | ADRB1 (0.54) | MAPTALDH1A1HTR6MEN1KMT2A | |
| SCHEMBL6283138 | 0.80 | MEN1 (0.46) | MAPTALDH1A1HTR6MEN1KMT2A | |
| SCHEMBL22957172 | 0.79 | SIGMAR1 (0.50) | HTR6PIM1ADRB1HTR2CHRH4 | |
| SCHEMBL8985943 | 0.76 | ADRB1 (0.57) | HDAC4MEF2DMAPTALDH1A1HTR6 | |
| SCHEMBL6762081 | 0.73 | PKM (0.55) | MAPTALDH1A1MEN1KMT2ATSHR | |
| Trifluoroacetic Acid SCHEMBL30282920 | 0.70 | LMNA (0.45) | ALDH1A1TSHRADRB1HRH4LMNA | |
| SCHEMBL9742229 | 0.68 | ADRB1 (0.56) | MAPTALDH1A1HTR6ADRB1ADRB2 | |
| SCHEMBL475387 | 0.66 | HDAC4 (0.61) | HDAC4MEF2DNTRK1HTR6MAOB | |
| SCHEMBL301359 | 0.64 | ADRB1 (0.62) | MAPTALDH1A1HTR6ADRB1DRD2 | |
| SCHEMBL28855158 | 0.63 | SIGMAR1 (0.57) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373247-A2 | SPIROISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079189-A2 | SPIROISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION AND INTERMEDIATES | TANABE SEIYAKU CO., LTD. (JP) | 2002-10-10 | — | — | WO | disclosed |