Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669198 | 0.77 | SIGMAR1 (0.38) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| SCHEMBL29807033 | 0.76 | GRIN2B (0.31) | KDM4EALDH1A1MEN1 | |
| SCHEMBL30666843 | 0.76 | GRIN2B (0.31) | KDM4EALDH1A1MEN1 | |
| SCHEMBL8845622 | 0.73 | SIGMAR1 (0.47) | SIGMAR1KDM1AALOX15TSHRMEN1 | |
| SCHEMBL6672827 | 0.72 | OPRM1 (0.43) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6669828 | 0.72 | HTR2A (0.36) | SIGMAR1KDM1ALMNAHTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6668923 | 0.71 | HTR2A (0.35) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| SCHEMBL6670168 | 0.70 | DRD2 (0.38) | SIGMAR1DRD2 | |
| SCHEMBL9722210 | 0.68 | MTNR1A (0.40) | KDM4EUSP2ALDH1A1LMNAMMP9 | |
| SCHEMBL11845112 | 0.65 | HTR2A (0.44) | KDM4EUSP2ALDH1A1LMNAMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |