Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | DRD3 | P35462 | 9/20 | 0.38 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669198 | 0.73 | SIGMAR1 (0.38) | DRD2SIGMAR1 | |
| SCHEMBL6670052 | 0.70 | SIGMAR1 (0.38) | DRD2SIGMAR1 | |
| SCHEMBL6672827 | 0.68 | OPRM1 (0.43) | OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6669828 | 0.68 | HTR2A (0.36) | DRD2OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6668923 | 0.67 | HTR2A (0.35) | DRD2SIGMAR1 | |
| SCHEMBL6396618 | 0.67 | SIGMAR1 (0.65) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL6910089 | 0.67 | PGR (0.56) | — | |
| SCHEMBL4621924 | 0.65 | ALDH1A1 (0.59) | — | |
| SCHEMBL6909959 | 0.64 | PGR (0.53) | — | |
| SCHEMBL7291994 | 0.63 | TSHR (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | claimed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | claimed |