Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.31 |
| ▸ | MITF | O75030 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681538 | 0.79 | MEN1 (0.34) | OPRM1OPRD1OPRK1ALDH1A1HTT | |
| SCHEMBL6677871 | 0.79 | AKR1C1 (0.34) | HCAR3HCAR2HTTCES1AKR1C1 | |
| SCHEMBL5614157 | 0.79 | HCAR3 (0.36) | HCAR3HCAR2OPRM1AKR1C1KIF11 | |
| SCHEMBL28890126 | 0.77 | AKR1C1 (0.46) | OPRM1ALDH1A1HTTCES1AKR1C1 | |
| SCHEMBL6681685 | 0.76 | AKR1C1 (0.34) | HTTCES1AKR1C1MEN1KMT2A | |
| SCHEMBL6677394 | 0.73 | AKR1C1 (0.37) | HTTAKR1C1CYP2D6MEN1KMT2A | |
| SCHEMBL6677071 | 0.72 | SMN1; SMN2 (0.36) | OPRM1OPRD1OPRK1ALDH1A1SLC6A4 | |
| SCHEMBL6637473 | 0.70 | AKR1C1 (0.30) | AKR1C1 | |
| SCHEMBL6680771 | 0.69 | AKR1C1 (0.37) | HCAR3HCAR2OPRM1HTTAKR1C1 | |
| SCHEMBL9807231 | 0.69 | HSD11B1 (0.35) | AKR1C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |