SCHEMBL668245

SCHEMBL668245

COc1cc(C(=O)Cl)cc(OC)c1OC(C)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 3/20 0.50
TUBB P07437 3/20 0.50
TUBA3C P0DPH7 3/20 0.50
TUBA1B P68363 3/20 0.50
TUBA4A P68366 3/20 0.50
TUBB4B P68371 3/20 0.50
TUBB3 Q13509 3/20 0.50
TUBB2A Q13885 3/20 0.50
TUBB8 Q3ZCM7 3/20 0.50
TUBA3E Q6PEY2 3/20 0.50
TUBA1A Q71U36 3/20 0.50
TUBA1C Q9BQE3 3/20 0.50
TUBB6 Q9BUF5 3/20 0.50
TUBB2B Q9BVA1 3/20 0.50
TUBB1 Q9H4B7 3/20 0.50
TSHR P16473 1/20 0.49
TOP1 P11387 3/20 0.46
TNFSF11 O14788 1/20 0.46
GRIN2D O15399 1/20 0.45
GRIN3B O60391 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8830632 0.89 TOP1 (0.57) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9887734 0.89 TSHR (0.43) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1928259 0.85 LMNA (0.62) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL219096 0.84 TUBB4A (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL28275397 0.84 TUBB4A (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL668055 0.83 TSHR (0.64) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23467799 0.81 TUBB1 (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL10926373 0.81 ABCB11 (0.53) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1808274 0.79 TSHR (0.63) TSHRTOP1TNFSF11TPMTALDH1A1
SCHEMBL16902988 0.79 HTT (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108368032-B Phenolic acid derivative compound and application thereof 大峰LS株式会社 2021-06-08 CN disclosed
US-10696623-B2 Phenolic acid derivative compound and use thereof DAEBONG LS, LTD (KR) 2020-06-30 US disclosed
US-20180362448-A1 NOVEL PHENOLIC ACID DERIVATIVE COMPOUND AND USE THEREOF DAEBONG LS, LTD (KR) 2018-12-20 US disclosed
EP-1601642-B1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX INTREXON CORP (US) 2017-01-04 EP disclosed
EP-1601642-B1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX INTREXON CORP (US) 2017-01-04 EP disclosed
EP-2463269-B1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORP (US) 2016-09-28 EP disclosed
EP-2463269-B1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORP (US) 2016-09-28 EP disclosed
US-9359289-B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORPORATION (US) 2016-06-07 US disclosed
US-9359289-B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORPORATION (US) 2016-06-07 US disclosed
US-9359289-B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORPORATION (US) 2016-06-07 US disclosed
US-20080064741-A1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RHEOGENE, INC. 2008-03-13 US disclosed
EP-1601642-A4 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RHEOGENE INC (US) 2007-04-11 EP disclosed
US-20060020146-A1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex RHEOGENE, INC. 2006-01-26 US disclosed
EP-1601642-A2 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RheoGene, Inc. (US) 2005-12-07 EP disclosed
WO-2004078924-A2 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RHEOGENE, INC. (US) 2004-09-16 WO disclosed
EP-0541798-B1 NEW DIAMINE COMPOUND AND BRAIN PROTECTING AGENT CONTAINING THE SAME KOWA CO (JP) 1995-11-29 EP disclosed
US-5389630-A Diamine compound and brain protecting agent containing the same KOWA CO., LTD. (JP) 1995-02-14 US disclosed
EP-0541798-A1 NEW DIAMINE COMPOUND AND BRAIN PROTECTING AGENT CONTAINING THE SAME Kowa Company Ltd. (JP) 1993-05-19 EP disclosed
US-4271193-A PROPHYLAXIS AND TREATMENT OF GASTRITIS KALI-CHEMIE PHARMA GMBH (DE) 1981-06-02 US disclosed
EP-0006458-A1 N1-Benzoyl-N2-phenyl-1,3-diaminopropane-2-ols and their salts, process for their preparation and medicaments containing them Kali-Chemie Pharma GmbH (DE) 1980-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10696623-B2 Phenolic acid derivative compound and use thereof TYR, COMT, PAH TUBB4A 3719/4885TUBB 3802/4885TUBA3C 4348/4885
US-20080064741-A1 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX NR2E3, NR5A1, NR5A2 TUBB4A 3694/4885TUBB 3549/4885TUBA3C 4409/4885
US-20180362448-A1 NOVEL PHENOLIC ACID DERIVATIVE COMPOUND AND USE THEREOF TYR, LPO, TH TUBB4A 3527/4885TUBB 3570/4885TUBA3C 4281/4885
US-20060020146-A1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex NR2E3, NR5A1, NR5A2 TUBB4A 3694/4885TUBB 3549/4885TUBA3C 4409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.