Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789030 | 0.89 | L3MBTL1 (0.42) | ALDH1A1NPSR1FABP7FABP5TP53 | |
| SCHEMBL6680969 | 0.86 | KDM4E (0.38) | ALDH1A1NPSR1KMT2AL3MBTL1 | |
| SCHEMBL6678209 | 0.85 | ALDH1A1 (0.38) | ALDH1A1P2RX3KMT2AL3MBTL1TSHR | |
| SCHEMBL6788504 | 0.84 | ALDH1A1 (0.39) | ALDH1A1NPSR1KMT2APKMTSHR | |
| SCHEMBL7127235 | 0.80 | ADORA2A (0.33) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6790883 | 0.79 | TP53 (0.36) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6679197 | 0.73 | ALDH1A1 (0.49) | ALDH1A1KMT2AL3MBTL1TSHR | |
| SCHEMBL7116975 | 0.71 | TP53 (0.35) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6679503 | 0.71 | TRPA1 (0.42) | ALDH1A1NPSR1TP53KMT2A | |
| SCHEMBL7125681 | 0.71 | L3MBTL1 (0.41) | ALDH1A1NPSR1FABP7FABP5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
| WO-2004014921-A1 | 5,6-FUSED URACIL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | ALDH1A1 812/4885ADORA3 1377/4885ADORA2A 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.