Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.88 |
| ▸ | MMP14 | P50281 | 13/20 | 0.88 |
| ▸ | MMP8 | P22894 | 10/20 | 0.88 |
| ▸ | MMP3 | P08254 | 9/20 | 0.88 |
| ▸ | MMP7 | P09237 | 4/20 | 0.88 |
| ▸ | MMP1 | P03956 | 14/20 | 0.74 |
| ▸ | MMP13 | P45452 | 15/20 | 0.71 |
| ▸ | MMP2 | P08253 | 8/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL6685375 | 0.94 | MMP14 (0.96) | MMP9MMP14MMP8MMP3MMP7 | |
| SCHEMBL6684445 | 0.94 | MMP14 (0.96) | MMP9MMP14MMP8MMP3MMP7 | |
| SCHEMBL5919470 | 0.94 | MMP14 (1.00) | MMP9MMP14MMP8MMP3MMP7 | |
| SCHEMBL6684680 | 0.93 | MMP14 (0.88) | MMP9MMP14MMP8MMP3MMP7 | |
| Acetic Acid SCHEMBL6687643 | 0.93 | MMP14 (0.95) | MMP9MMP14MMP8MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6461484 | 0.93 | MMP14 (0.98) | MMP9MMP14MMP8MMP3MMP7 | |
| Phosphoric Acid SCHEMBL6688569 | 0.91 | MMP14 (0.95) | MMP9MMP14MMP8MMP3MMP7 | |
| SCHEMBL5919236 | 0.89 | MMP13 (0.80) | MMP9MMP14MMP8MMP3MMP7 | |
| Citric Acid SCHEMBL6687662 | 0.88 | MMP14 (0.84) | MMP9MMP14MMP8MMP3MMP7 | |
| SCHEMBL6686540 | 0.88 | MMP9 (0.75) | MMP9MMP14MMP8MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-11-25 | — | — | US | disclosed |
| US-6750228-B1 | UNCONTROLLED BREAKDOWN OF CONNECTIVE TISSUE BY METALLOPROTEASES IS A FEATURE OF MANY PATHOLOGICAL CONDITIONS | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP9, MMP13, MMP2 | MMP9 1/4885MMP14 7/4885MMP8 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.