Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750054 | 1.00 | LMNA (0.42) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL12684655 | 1.00 | LMNA (0.42) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL29920 | 1.00 | LMNA (0.42) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL21885889 | 1.00 | LMNA (0.42) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL151903 | 0.91 | LMNA (0.40) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL1687120 | 0.90 | THRB (0.37) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL891846 | 0.88 | LMNA (0.41) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL6448213 | 0.88 | LMNA (0.41) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL2985499 | 0.88 | LMNA (0.41) | LMNAL3MBTL1TDP1THRBCYP2D6 | |
| SCHEMBL3168782 | 0.88 | LMNA (0.41) | LMNAL3MBTL1TDP1THRBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242569-A1 | PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE | 2023-08-03 | — | — | US | disclosed |
| US-20230212204-A1 | REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS | THE SCRIPPS RESEARCH INSTITUTE | 2023-07-06 | — | — | US | disclosed |
| US-11613554-B2 | Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-03-28 | — | — | US | disclosed |
| US-20220143064-A1 | TAU ANTISENSE OLIGOMERS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2022-05-12 | — | — | US | disclosed |
| WO-2021242755-A1 | LOW DISHING OXIDE CMP POLISHING COMPOSITIONS FOR SHALLOW TRENCH ISOLATION APPLICATIONS AND METHODS OF MAKING THEREOF | VERSUM MATERIALS US, LLC (US) | 2021-12-02 | — | — | WO | disclosed |
| US-11077132-B2 | Tau antisense oligomers and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2021-08-03 | — | — | US | disclosed |
| US-10799523-B2 | Tau antisense oligomers and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2020-10-13 | — | — | US | disclosed |
| EP-3653712-A1 | TAU ANTISENSE OLIGOMERS AND USES THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2020-05-20 | — | — | EP | disclosed |
| US-20190322694-A1 | NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE | 2019-10-24 | — | — | US | disclosed |
| US-20180161356-A1 | TAU ANTISENSE OLIGOMERS AND USES THEREOF | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2018-06-14 | — | — | US | disclosed |
| US-9394270-B2 | Cytotoxin compounds and methods of isolation | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-19 | — | — | US | disclosed |
| US-20140194495-A1 | CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION | THE UAB RESEARCH FOUNDATION (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140194495-A1 | CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION | THE UAB RESEARCH FOUNDATION (US) | 2014-07-10 | — | — | US | disclosed |
| US-8669376-B2 | Cytotoxin compounds and methods of isolation | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-03-11 | — | — | US | disclosed |
| US-8669376-B2 | Cytotoxin compounds and methods of isolation | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-03-11 | — | — | US | disclosed |
| US-20090192215-A1 | Cytotoxin Compounds and Methods of Isolation | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-07-30 | — | — | US | disclosed |
| US-20090192215-A1 | Cytotoxin Compounds and Methods of Isolation | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-07-30 | — | — | US | disclosed |
| WO-2007035734-A2 | CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2007-03-29 | — | — | WO | disclosed |
| US-20040033967-A1 | Alkylated hexitol nucleoside analogues and oligomers thereof | K.U.LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2004-02-19 | — | — | US | disclosed |
| WO-2002018406-A1 | ALKYLATED HEXITOL NUCLEOSIDE ANALOGUES AND OLIGOMERS THEREOF | K.U.LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161356-A1 | TAU ANTISENSE OLIGOMERS AND USES THEREOF | MAPT, FUS, TARDBP | LMNA 2316/4885L3MBTL1 308/4885TDP1 152/4885 |
| US-20230242569-A1 | PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | PPIP5K2, INPP5B, PTMS | LMNA 2930/4885L3MBTL1 2573/4885TDP1 2235/4885 |
| US-20140194495-A1 | CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION | XPA, ANXA5, ST14 | LMNA 524/4885L3MBTL1 1728/4885TDP1 2201/4885 |
| US-20090192215-A1 | Cytotoxin Compounds and Methods of Isolation | XPA, ANXA5, ST14 | LMNA 524/4885L3MBTL1 1728/4885TDP1 2201/4885 |
| US-20040033967-A1 | Alkylated hexitol nucleoside analogues and oligomers thereof | DERA, HEXA, HEXB | LMNA 1261/4885L3MBTL1 745/4885TDP1 1542/4885 |
| US-10799523-B2 | Tau antisense oligomers and uses thereof | MAPT, FUS, TARDBP | LMNA 2316/4885L3MBTL1 308/4885TDP1 152/4885 |
| US-20220143064-A1 | TAU ANTISENSE OLIGOMERS AND USES THEREOF | MAPT, FUS, TARDBP | LMNA 2316/4885L3MBTL1 308/4885TDP1 152/4885 |
| US-11613554-B2 | Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds | PPIP5K2, INPP5B, PTMS | LMNA 2930/4885L3MBTL1 2573/4885TDP1 2235/4885 |
| US-11077132-B2 | Tau antisense oligomers and uses thereof | MAPT, FUS, TARDBP | LMNA 2316/4885L3MBTL1 308/4885TDP1 152/4885 |
| US-20190322694-A1 | NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | PPIP5K2, INPP5B, PTMS | LMNA 3123/4885L3MBTL1 2862/4885TDP1 2209/4885 |
| US-20230212204-A1 | REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS | PNKP, POLL, RNGTT | LMNA 3270/4885L3MBTL1 1222/4885TDP1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.