SCHEMBL7590002

SCHEMBL7590002

Clc1ccc(C2=NC(c3cc(Cl)cc(Cl)c3Cl)(n3c(-c4cc(Cl)cc(Cl)c4Cl)nc(-c4ccc(Cl)cc4)c3-c3ccc(Cl)cc3)N=C2c2ccc(Cl)cc2)cc1

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30
GAA P10253 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6693283 0.93 GAA (0.33) KDM4ELMNAGAAL3MBTL1
SCHEMBL476565 0.76 HSD11B1 (0.42) KDM4ELMNAGAAL3MBTL1
SCHEMBL29389827 0.76 HSD11B1 (0.42) KDM4ELMNAGAAL3MBTL1
SCHEMBL16746551 0.75 P2RX7 (0.34) KDM4ELMNAGAAL3MBTL1
SCHEMBL1868574 0.71 MGAM (0.42) GAA
SCHEMBL307038 0.70 HSD11B1 (0.37) KDM4ELMNAGAAL3MBTL1
SCHEMBL29359500 0.70 HSD11B1 (0.37) KDM4ELMNAGAAL3MBTL1
SCHEMBL29749791 0.70 HSD11B1 (0.37) KDM4ELMNAGAAL3MBTL1
SCHEMBL476551 0.70 GAA (0.38) KDM4ELMNAGAAL3MBTL1
SCHEMBL30358509 0.70 L3MBTL1 (0.39) KDM4ELMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0764283-B1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING THE ELEMENTS DU PONT (US) 2002-04-24 EP disclosed
EP-0764283-A1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING AND USING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-03-26 EP disclosed
US-5526145-A Color tuned holographic optical elements and methods of making and using the elements E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-06-11 US disclosed
WO-1995034833-A1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING AND USING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-12-21 WO disclosed