Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11708734 | 0.77 | MIF (0.46) | L3MBTL1MIFALDH1A1HPGDHSD17B10 | |
| SCHEMBL5954570 | 0.77 | MIF (0.64) | MIFALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL484042 | 0.76 | MIF (0.54) | MIFALDH1A1MAPTUSP2HPGD | |
| SCHEMBL2225278 | 0.74 | L3MBTL1 (0.70) | L3MBTL1EHMT2EHMT1APOBEC3GALDH1A1 | |
| SCHEMBL30634505 | 0.74 | L3MBTL1 (0.70) | L3MBTL1EHMT2EHMT1APOBEC3GALDH1A1 | |
| SCHEMBL9633862 | 0.74 | ALDH1A1 (0.47) | L3MBTL1MIFEHMT2EHMT1APOBEC3G | |
| SCHEMBL6211797 | 0.74 | DDAH1 (0.54) | MIFALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4682214 | 0.73 | L3MBTL1 (0.96) | L3MBTL1EHMT2EHMT1APOBEC3GALDH1A1 | |
| SCHEMBL11711212 | 0.73 | L3MBTL1 (0.42) | L3MBTL1MIFALDH1A1MEN1MAPT | |
| SCHEMBL11711554 | 0.72 | HAO1 (0.41) | MIFALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | PFIZER, INC. | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | MKI67, TK1, CDK2 | L3MBTL1 3002/4885MIF 962/4885EHMT2 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.