SCHEMBL670308

SCHEMBL670308

O=C1NCC2(CCN(C(=O)O)CC2)O1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.51
CHRM2 P08172 1/20 0.51
ADRA2A P08913 1/20 0.51
CYP2D6 P10635 1/20 0.51
TSHR P16473 1/20 0.51
DRD1 P21728 1/20 0.51
MAPT P10636 1/20 0.50
KMT2A Q03164 1/20 0.50
HDAC1 Q13547 6/20 0.38
KCNH2 Q12809 2/20 0.36
CYP11B2 P19099 1/20 0.36
CDK8 P49336 4/20 0.35
CDK19 Q9BWU1 4/20 0.35
SMO Q99835 1/20 0.35
CHRNA7 P36544 2/20 0.35
CCNC P24863 3/20 0.34
PDCD1LG2 Q9BQ51 1/20 0.34
CD274 Q9NZQ7 1/20 0.34
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18072235 0.85 TSHR (0.47) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL23131110 0.85 LMNA (0.47) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL17760301 0.85 LMNA (0.38) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL22770999 0.82 LMNA (0.40) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL16614241 0.82 LMNA (0.45) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL4141809 0.82 LMNA (0.45) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL16001316 0.82 TSHR (0.45) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL1911519 0.81 LMNA (0.44) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL25374346 0.81 LMNA (0.41) LMNACHRM2ADRA2ACYP2D6TSHR
SCHEMBL22174114 0.81 LMNA (0.44) LMNACHRM2ADRA2ACYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4225752-A1 SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES Idorsia Pharmaceuticals Ltd (CH) 2023-08-16 EP claimed
EP-3661941-B1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2022-12-14 EP claimed
WO-2022073969-A1 SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES IDORSIA PHARMACEUTICALS LTD (CH) 2022-04-14 WO claimed
US-11186592-B2 Thiazolopyridine derivatives as adenosine receptor antagonists MERCK PATENT GMBH (DE) 2021-11-30 US claimed
US-20200181171-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2020-06-11 US claimed
EP-3661941-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS Merck Patent GmbH (DE) 2020-06-10 EP claimed
WO-2019025099-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2019-02-07 WO claimed
US-12312362-B2 Spiro derivatives of Alpha-D-galactopyranosides IDORSIA PHARMACEUTICALS LTD (CH) 2025-05-27 US disclosed
EP-4126855-B1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS HOFFMANN LA ROCHE (CH) 2024-04-24 EP disclosed
EP-4271673-A1 INDAZOLE COMPOUNDS AS KINASE INHIBITORS Tyra Biosciences, Inc. (US) 2023-11-08 EP disclosed
US-20230295182-A1 SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES IDORSIA PHARMACEUTICALS LTD (CH) 2023-09-21 US disclosed
EP-4225752-A1 SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES Idorsia Pharmaceuticals Ltd (CH) 2023-08-16 EP disclosed
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION HOFFMANN-LA ROCHE INC. (US) 2023-06-01 US disclosed
EP-3207030-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Merck Sharp & Dohme Corp. (US) 2017-08-23 EP disclosed
WO-2017021805-A1 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS PFIZER INC. (US) 2017-02-09 WO disclosed
US-20170029390-A1 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS PFIZER INC. (US) 2017-02-02 US disclosed
US-20160214935-A1 AUTOTAXIN INHIBITOR COMPOUNDS DF 2024 IP ACQUISITION, LLC 2016-07-28 US disclosed
WO-2016060941-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME CORP. (US) 2016-04-21 WO disclosed
EP-2605658-A1 SPIROXAZOLIDINONE COMPOUNDS Merck Sharp & Dohme Corp. (US) 2013-06-26 EP disclosed
WO-2012024183-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2012-02-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170029390-A1 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS MAG, PYM1, HIF1AN LMNA 2311/4885CHRM2 3154/4885ADRA2A 2850/4885
US-11186592-B2 Thiazolopyridine derivatives as adenosine receptor antagonists ADORA1, ADORA2A, AMPD2 LMNA 3726/4885CHRM2 2214/4885ADRA2A 332/4885
US-20160214935-A1 AUTOTAXIN INHIBITOR COMPOUNDS ENPP2, SERPINB1, SERPINE1 LMNA 1232/4885CHRM2 4679/4885ADRA2A 3941/4885
US-20200181171-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS ADORA1, ADORA2A, AMPD2 LMNA 3726/4885CHRM2 2214/4885ADRA2A 332/4885
US-12312362-B2 Spiro derivatives of Alpha-D-galactopyranosides LGALS1, LGALS3, LGALS2 LMNA 924/4885CHRM2 1679/4885ADRA2A 211/4885
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION LTB4R, C5, C3AR1 LMNA 2441/4885CHRM2 444/4885ADRA2A 895/4885
US-20230295182-A1 SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES LGALS1, LGALS3, LGALS2 LMNA 924/4885CHRM2 1679/4885ADRA2A 211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.