Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398615 | 0.83 | ALDH1A1 (0.54) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL8316805 | 0.82 | CCNB2 (0.48) | KMT2ANPC1RAB9AMIFHPGD | |
| SCHEMBL1121674 | 0.80 | NPC1 (0.53) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL11736051 | 0.79 | L3MBTL1 (0.54) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL2213224 | 0.78 | HPGD (0.56) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL8639480 | 0.77 | NPC1 (0.50) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL11738365 | 0.77 | RAB9A (0.61) | NPC1RAB9AHPGDMAPTALDH1A1 | |
| SCHEMBL1520869 | 0.77 | NPC1 (0.53) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL11171960 | 0.76 | L3MBTL1 (0.49) | KMT2ANPC1RAB9AHPGDMAPT | |
| SCHEMBL13610029 | 0.76 | RAB9A (0.40) | KMT2ANPC1RAB9AMIFHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116490-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | disclosed |
| EP-1381360-A1 | COMPOUNDS AND METHODS FOR INHIBITING METAP2 IN MAMMALS | SmithKline Beecham Corporation (US) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002078697-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
| US-20020007060-A1 | Reverse hydroxamate inhibitors of matrix metalloproteinases | DAVIDSEN STEVEN K (US) | 2002-01-17 | — | — | US | disclosed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020007060-A1 | Reverse hydroxamate inhibitors of matrix metalloproteinases | MMP1, MMP9, MMP3 | KMT2A 2306/4885NPC1 2824/4885RAB9A 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.