Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.46 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.43 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29647872 | 1.00 | HIF1A (0.52) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL30959846 | 1.00 | HIF1A (0.52) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL27180519 | 0.99 | HIF1A (0.51) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL164701 | 0.94 | PHLPP2 (0.53) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL30142620 | 0.94 | PHLPP2 (0.53) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| Water SCHEMBL29486368 | 0.93 | PHLPP2 (0.52) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL15226561 | 0.91 | PHLPP2 (0.50) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| Hydroxyamine SCHEMBL16653989 | 0.91 | PHLPP2 (0.50) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| Butane SCHEMBL10710653 | 0.89 | PHLPP2 (0.48) | HIF1AKDM4ELMNASMN1; SMN2MITF | |
| SCHEMBL164702 | 0.88 | PHLPP2 (0.57) | HIF1AKDM4ELMNASMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179273-A1 | A METHOD FOR DETERMINING TOTAL IRON IN AQUEOUS SOLUTIONS | Water Lens, LLC (US) | 2015-11-26 | — | — | WO | claimed |
| CN-116286860-A | Cotton encoding bHLH gene GhbHLH121 and application thereof | 浙江大学 | 2023-06-23 | — | — | CN | disclosed |
| EP-2681228-B1 | PLATINUM COMPLEXES AND THEIR USE | Westfälische Wilhelms-Universität Münster (DE) | 2016-12-21 | — | — | EP | disclosed |
| WO-2016149637-A1 | NANOPLATFORMS FOR ARGINASE, INDOLEAMINE 2,3-DIOXYGENASE AND TRYPTOPHAN 2,3-DIOXYGENASE DETECTION BY POSTTRANSLATIONAL MODIFICATION | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-09-22 | — | — | WO | disclosed |
| WO-2015179273-A1 | A METHOD FOR DETERMINING TOTAL IRON IN AQUEOUS SOLUTIONS | Water Lens, LLC (US) | 2015-11-26 | — | — | WO | disclosed |
| US-8422202-B2 | Capacitor and method for manufacturing the same | SHIN-ETSU POLYMER CO., LTD. (JP) | 2013-04-16 | — | — | US | disclosed |
| JP-2004006410-A | NONAQUEOUS SECONDARY BATTERY | UBE IND LTD | 2004-01-08 | — | — | JP | disclosed |
| EP-0763512-A1 | AIR BAG GAS GENERATING AGENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-03-19 | — | — | EP | disclosed |