Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618492 | 0.88 | ALDH1A1 (0.81) | ALDH1A1HTR7SMN1; SMN2HTR1BMAPK1 | |
| SCHEMBL10633020 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2ADRA2BPTGS1TDP1 | |
| SCHEMBL23579204 | 0.79 | HTR7 (0.56) | ALDH1A1HTR7HTR1BNOS3NOS1 | |
| SCHEMBL29975085 | 0.79 | HTR7 (0.56) | ALDH1A1HTR7HTR1BNOS3NOS1 | |
| SCHEMBL8068646 | 0.79 | KDM4E (0.49) | ALDH1A1HTR7HTR1BKEAP1NFE2L2 | |
| SCHEMBL3893843 | 0.78 | HTR7 (0.62) | ALDH1A1HTR7SMN1; SMN2HTR1BNOS3 | |
| SCHEMBL10353929 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2ADRA2BPTGS1TDP1 | |
| SCHEMBL2820615 | 0.77 | ALDH1A1 (0.65) | ALDH1A1HTR7SMN1; SMN2HTR1BMAPK1 | |
| SCHEMBL11209770 | 0.77 | ALDH1A1 (0.65) | ALDH1A1HTR7SMN1; SMN2HTR1BDRD2 | |
| SCHEMBL4703459 | 0.77 | HTR1B (0.54) | ALDH1A1HTR7SMN1; SMN2HTR1BNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174485-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174485-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174485-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2023-06-08 | — | — | US | disclosed |
| EP-4125874-A1 | LIPOXYGENASE INHIBITORS | SRI International (US) | 2023-02-08 | — | — | EP | disclosed |
| CN-115335046-A | Lipoxygenase inhibitors | 思研（SRI）国际顾问与咨询公司 | 2022-11-11 | — | — | CN | disclosed |
| WO-2021195346-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021195346-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2021-09-30 | — | — | WO | disclosed |
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | HUSSON HENRI-PHILIPPE (FR) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | SCN11A, CYP4A11, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ALDH1A1 1498/4885HTR7 930/4885SMN1; SMN2 4636/4885 |
| US-20230174485-A1 | LIPOXYGENASE INHIBITORS | ALOX15B, ALOX12, ALOX15 | ALDH1A1 133/4885HTR7 2208/4885SMN1; SMN2 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.