Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955251 | 0.88 | LMNA (0.66) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5955247 | 0.88 | LMNA (0.66) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5954468 | 0.87 | ALDH1A1 (0.62) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5954359 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL30450762 | 0.83 | HPGD (0.64) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2960871 | 0.82 | CA12 (0.62) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6715971 | 0.82 | PPARG (0.63) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL17010274 | 0.82 | L3MBTL1 (0.61) | ALDH1A1LMNAL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL9483448 | 0.81 | RAB9A (0.76) | ALDH1A1RAB9ASMN1; SMN2NPC1LTA4H | |
| SCHEMBL2716599 | 0.79 | LMNA (0.68) | ALDH1A1LMNAL3MBTL1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040024001-A1 | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases | BRISTOL-MYERS SQUIBB COMPANY | 2004-02-05 | — | — | US | disclosed |
| WO-2003091252-A1 | SPIROBARBITURIC ACID DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024001-A1 | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases | MMP13, MMP3, MMP1 | ALDH1A1 374/4885LMNA 719/4885L3MBTL1 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.