Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723591 | 0.93 | THRA (0.46) | ALDH1A1MAPK1L3MBTL1CDC25BLMNA | |
| SCHEMBL6723918 | 0.87 | ALDH1A1 (0.47) | ALDH1A1MAPK1L3MBTL1CDC25BLMNA | |
| SCHEMBL6725854 | 0.85 | LMNA (0.42) | ALDH1A1MAPK1L3MBTL1CDC25BLMNA | |
| SCHEMBL6731605 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPK1L3MBTL1CDC25BLMNA | |
| SCHEMBL6820149 | 0.82 | MEN1 (0.43) | ALDH1A1LMNAKDM4EHPGDTHRA | |
| SCHEMBL22991665 | 0.79 | CDC25B (0.46) | ALDH1A1MAPK1L3MBTL1CDC25BLMNA | |
| SCHEMBL6720881 | 0.78 | THRB (0.49) | ALDH1A1LMNATHRATHRBKMT2A | |
| SCHEMBL6725779 | 0.77 | KMT2A (0.64) | ALDH1A1L3MBTL1LMNAHPGDKMT2A | |
| SCHEMBL6725044 | 0.75 | F2 (0.46) | LMNAHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6720862 | 0.74 | KMT2A (0.45) | ALDH1A1MAPK1L3MBTL1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |