Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 6/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731605 | 0.97 | ALDH1A1 (0.45) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL6723591 | 0.95 | THRA (0.46) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL6721180 | 0.87 | ALDH1A1 (0.43) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL7754025 | 0.85 | FFAR1 (0.37) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL22991665 | 0.83 | CDC25B (0.46) | ALDH1A1MAPK1L3MBTL1LMNAKDM4E | |
| SCHEMBL6725854 | 0.80 | LMNA (0.42) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL6728497 | 0.78 | THRA (0.61) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL4269670 | 0.76 | MEN1 (0.63) | THRATHRBLMNAKMT2ASRD5A2 | |
| SCHEMBL6720862 | 0.76 | KMT2A (0.45) | ALDH1A1MAPK1L3MBTL1THRATHRB | |
| SCHEMBL6728507 | 0.76 | MEN1 (0.49) | ALDH1A1L3MBTL1THRATHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |