Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 6/20 | 0.47 |
| ▸ | THRA | P10827 | 5/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TTR | P02766 | 3/20 | 0.39 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820149 | 0.92 | MEN1 (0.43) | MEN1KMT2AHPGDALDH1A1THRB | |
| SCHEMBL6725936 | 0.85 | GAA (0.40) | MEN1KMT2AHPGDALDH1A1THRB | |
| SCHEMBL6723591 | 0.82 | THRA (0.46) | KMT2AHPGDALDH1A1THRBTHRA | |
| SCHEMBL6725180 | 0.80 | THRB (0.55) | MEN1KMT2AALDH1A1THRBTHRA | |
| SCHEMBL6725083 | 0.80 | ESR1 (0.49) | MEN1KMT2AHPGDALDH1A1ELANE | |
| SCHEMBL6728497 | 0.76 | THRA (0.61) | MEN1KMT2AALDH1A1THRBTHRA | |
| SCHEMBL6723918 | 0.76 | ALDH1A1 (0.47) | KMT2AALDH1A1THRBTHRATDP1 | |
| SCHEMBL6721180 | 0.74 | ALDH1A1 (0.43) | MEN1KMT2AHPGDALDH1A1THRB | |
| SCHEMBL6731605 | 0.74 | ALDH1A1 (0.45) | KMT2AHPGDALDH1A1THRBTHRA | |
| SCHEMBL6724871 | 0.73 | THRA (0.57) | KMT2ATHRBTHRAELANEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |