Sugi Predict

Sugi Predict / Compounds / SCHEMBL6731937

SCHEMBL6731937

SCHEMBL6731937

CS(=O)(=O)c1cc(F)c(-c2csc(=O)n2-c2cccc(Cl)c2)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.39
▸ CCR2 P41597 3/20 0.34
▸ PTGS2 P35354 3/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ PTGS1 P23219 1/20 0.33
▸ RGS4 P49798 1/20 0.32
▸ RGS8 P57771 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ PTGER1 P34995 1/20 0.32
▸ MAPT P10636 4/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ SMPD1 P17405 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6731817 0.90 PTGS2 (0.38) PTGS2PTGS1MEN1KMT2A
SCHEMBL6739469 0.89 PTGS2 (0.39) ALDH1A1PTGS2CA12CA1CA2
SCHEMBL6737579 0.89 MAPT (0.35) ALDH1A1PTGS2PTGS1RGS4RGS8
SCHEMBL6734751 0.89 CCR2 (0.36) ALDH1A1CCR2PTGS2CA12CA1
SCHEMBL6735809 0.89 CCR2 (0.32) CCR2PTGS2
SCHEMBL6739351 0.89 ACLY (0.34) PTGS2CA12CA1CA2CA9
SCHEMBL6739209 0.88 GSK3A (0.40) ALDH1A1PTGER1MEN1KMT2ALMNA
SCHEMBL6740069 0.87 PTGS2 (0.41) PTGS2PTGS1
SCHEMBL6736524 0.87 SCN9A (0.33) PTGS2PTGS1RGS4RGS8MEN1
SCHEMBL6736443 0.86 CYP1A2 (0.38) ALDH1A1CYP1A2RGS4RGS8MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885CCR2 37/4885PTGS2 10/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885CCR2 37/4885PTGS2 10/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885CCR2 37/4885PTGS2 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.