Sugi Predict

Sugi Predict / Compounds / SCHEMBL6737579

SCHEMBL6737579

SCHEMBL6737579

Cc1cccc(-n2c(-c3cc(F)c(S(C)(=O)=O)cc3F)csc2=O)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ PTGS1 P23219 2/20 0.34
▸ PTGS2 P35354 2/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ CRHBP P24387 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ CRHR2 Q13324 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ HPGD P15428 4/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ RGS4 P49798 1/20 0.33
▸ RGS8 P57771 1/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ MGLL Q99685 1/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6731817 0.90 PTGS2 (0.38) PTGS1PTGS2MEN1KMT2AMGLL
SCHEMBL6731937 0.89 ALDH1A1 (0.39) MAPTLMNATP53PTGS1PTGS2
SCHEMBL6735981 0.89 PTGS2 (0.30) PTGS2
SCHEMBL6739351 0.89 ACLY (0.34) PTGS1PTGS2
SCHEMBL6739209 0.88 GSK3A (0.40) LMNAALDH1A1MEN1KMT2AMGLL
SCHEMBL6740550 0.87 PTGS2 (0.37) MAPTPTGS1PTGS2ALDH1A1NPC1
SCHEMBL6736443 0.86 CYP1A2 (0.38) MAPTLMNATP53ALDH1A1MEN1
SCHEMBL6777667 0.85 PTGS2 (0.35) MAPTTP53PTGS1PTGS2ALDH1A1
SCHEMBL6728770 0.85 PTGS2 (0.36) PTGS1PTGS2KMT2A
SCHEMBL6739300 0.85 PTGS2 (0.36) LMNAPTGS1PTGS2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 MAPT 4545/4885LMNA 2247/4885TP53 999/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 MAPT 4545/4885LMNA 2247/4885TP53 999/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 MAPT 4545/4885LMNA 2247/4885TP53 999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.