Sugi Predict

Sugi Predict / Compounds / SCHEMBL6736934

SCHEMBL6736934

SCHEMBL6736934

CS(=O)(=O)c1cc(F)c(-c2nc(C(F)F)[nH]c2-c2ccc(Cl)cc2)cc1F

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 10/20 0.42
▸ PTGS1 P23219 5/20 0.42
▸ ALOX5 P09917 1/20 0.36
▸ TYK2 P29597 3/20 0.35
▸ TP53 P04637 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ CCR2 P41597 1/20 0.34
▸ MAPK13 O15264 1/20 0.34
▸ GCGR P47871 1/20 0.34
▸ MAPK12 P53778 1/20 0.34
▸ MAPK11 Q15759 1/20 0.34
▸ MAPK14 Q16539 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6731912 0.91 ALOX5 (0.44) PTGS2PTGS1ALOX5MAPK13MAPK12
SCHEMBL6733537 0.91 TYK2 (0.33) PTGS2PTGS1ALOX5TYK2CCR2
SCHEMBL6732359 0.90 ALOX5 (0.35) PTGS2PTGS1ALOX5MAPK14
SCHEMBL6734417 0.90 ALDH1A1 (0.41) PTGS2PTGS1ALOX5TYK2MAPK13
SCHEMBL6732424 0.89 SCN9A (0.38) PTGS2PTGS1ALOX5TYK2
SCHEMBL6728986 0.89 ALOX5 (0.36) PTGS2PTGS1ALOX5MAPK13GCGR
SCHEMBL6739660 0.89 ALDH1A1 (0.43) PTGS2PTGS1ALOX5MAPK14
SCHEMBL6733333 0.89 IDO1 (0.39) PTGS2ALOX5TYK2MAPK13MAPK12
SCHEMBL6729810 0.88 PTGS2 (0.42) PTGS2PTGS1ALOX5TYK2MAPK14
SCHEMBL6734473 0.88 PTGS2 (0.45) PTGS2PTGS1ALOX5TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US claimed
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.