Sugi Predict

Sugi Predict / Compounds / SCHEMBL6739660

SCHEMBL6739660

SCHEMBL6739660

CS(=O)(=O)c1cc(F)c(-c2nc(C(F)F)[nH]c2-c2ccccc2)cc1F

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ ALOX5 P09917 2/20 0.40
▸ PTGS1 P23219 5/20 0.39
▸ PTGS2 P35354 5/20 0.39
▸ ACLY P53396 1/20 0.37
▸ MAPK14 Q16539 2/20 0.36
▸ ALOX5AP P20292 1/20 0.34
▸ FEN1 P39748 1/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6731912 0.91 ALOX5 (0.44) ALDH1A1ALOX5PTGS1PTGS2MAPK14
SCHEMBL6736125 0.90 SCD (0.37) ALDH1A1HPGDALOX5PTGS2MAPK14
SCHEMBL6734417 0.90 ALDH1A1 (0.41) ALDH1A1KDM4EALOX5PTGS1PTGS2
SCHEMBL6732500 0.89 MAPK14 (0.39) ALDH1A1HPGDALOX5PTGS1PTGS2
SCHEMBL6736934 0.89 PTGS2 (0.42) ALOX5PTGS1PTGS2MAPK14
SCHEMBL6728986 0.89 ALOX5 (0.36) ALDH1A1HPGDALOX5PTGS1PTGS2
SCHEMBL6732502 0.88 ALOX5 (0.34) ALDH1A1ALOX5PTGS1PTGS2MAPK14
SCHEMBL6734086 0.88 MAPK13 (0.35) ALDH1A1HPGDKDM4EALOX5PTGS2
SCHEMBL6735431 0.88 LMNA (0.40) ALOX5PTGS1PTGS2NR1H2NR1H3
SCHEMBL6733333 0.88 IDO1 (0.39) ALOX5PTGS2MAPK14NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US claimed
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885HPGD 917/4885KDM4E 3382/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885HPGD 917/4885KDM4E 3382/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 ALDH1A1 434/4885HPGD 917/4885KDM4E 3382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.