SCHEMBL674063

SCHEMBL674063

Oc1cc(O)cc(C#Cc2cc(O)cc(O)c2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.57
APP P05067 4/20 0.43
ABL1 P00519 2/20 0.43
ABCB1 P08183 2/20 0.43
BCR P11274 2/20 0.43
LCK P06239 1/20 0.40
ACHE P22303 1/20 0.38
CA12 O43570 7/20 0.38
CA9 Q16790 7/20 0.38
CA2 P00918 6/20 0.38
CA14 Q9ULX7 6/20 0.38
ALDH1A1 P00352 5/20 0.38
CA5A P35218 5/20 0.38
CA1 P00915 5/20 0.38
CA5B Q9Y2D0 4/20 0.38
LMNA P02545 4/20 0.38
CYP3A4 P08684 4/20 0.38
HSD17B10 Q99714 4/20 0.38
CA3 P07451 4/20 0.38
CA4 P22748 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL673158 0.88 APP (0.61) BACE1APPABL1ABCB1BCR
SCHEMBL4267409 0.84 APP (0.60) BACE1APPABL1ABCB1BCR
SCHEMBL12535886 0.84 ALDH1A1 (0.57) BACE1APPABL1ABCB1BCR
SCHEMBL19026498 0.82 APP (0.57) APPCA12CA9CA2CA1
SCHEMBL4267440 0.80 ALOX5 (0.43) BACE1APPABL1ABCB1BCR
SCHEMBL4277452 0.80 PTGS1 (0.47) BACE1APPCA12CA9CA2
SCHEMBL4267390 0.80 ACHE (0.52) BACE1APPACHECA12CA9
SCHEMBL4264799 0.80 APP (0.46) BACE1APPCA12CA9CA2
SCHEMBL22708286 0.78 BACE1 (0.40) BACE1APPABL1ABCB1BCR
SCHEMBL20211704 0.78 APP (0.60) APPCA12CA9CA2CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 US claimed
US-20210228501-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2021-07-29 US claimed
US-10426742-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2019-10-01 US claimed
US-20190022029-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2019-01-24 US claimed
EP-3280402-A2 FORMULATION AND PROCESS FOR MODULATING WOUND HEALING Biomendics LLC (US) 2018-02-14 EP claimed
WO-2016164531-A2 FORMULATION AND PROCESS FOR MODULATING WOUND HEALING BioMendics, LLC (US) 2016-10-13 WO claimed
US-20160296477-A1 Formulation and Process for Modulating Wound Healing BioMendics, LLC (US) 2016-10-13 US claimed
US-8680142-B2 Ascorbate, vitamin K3 and hydroxytolans in the treatment of cancer KENT STATE UNIVERSITY (US) 2014-03-25 US claimed
EP-3280402-B1 TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING BIOMENDICS LLC (US) 2024-06-05 EP disclosed
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 US disclosed
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 US disclosed
US-11786481-B2 Formulation and process for modulating wound healing BioMendics, LLC (US) 2023-10-17 US disclosed
US-20220296538-A1 Substituted Tolans for the Modulation of Microbial Colonization BioMendics, LLC (US) 2022-09-22 US disclosed
US-11351126-B2 Substituted tolans for the modulation of microbial colonization BioMendics, LLC (US) 2022-06-07 US disclosed
WO-2009126700-A1 HYDROXYLATED TOLANS AND RELATED COMPOUNDS AS COSMETICS OR THERAPEUTICS FOR SKIN CONDITIONS KENT STATE UNIVERSITY (US) 2009-10-15 WO disclosed
WO-2008157745-A1 ASCORBATE, VITAMIN K3 AND HYDROXYTOLANS IN THE TREATMENT OF CANCER KENT STATE UNIVERSITY (US) 2008-12-24 WO disclosed
WO-2008157787-A2 HYDROXYLATED TOLANS AND RELATED COMPOUNDS IN THE TREATMENT OF CANCER KENT STATE UNIVERSITY (US) 2008-12-24 WO disclosed
WO-2008157787-A2 HYDROXYLATED TOLANS AND RELATED COMPOUNDS IN THE TREATMENT OF CANCER KENT STATE UNIVERSITY (US) 2008-12-24 WO disclosed
US-7094809-B2 Topical administration of dihydroxytoluene to block viral replication NORTHEASTERN OHIO UNIVERSITIES COLLEGE OF MEDICINE (US) 2006-08-22 US disclosed
US-20030203974-A1 Methods for treating subjects infected with herpes virus or Neisseria gonorrheae DOCHERTY JOHN (US) 2003-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11786481-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB BACE1 4779/4885APP 4010/4885ABL1 2543/4885
US-20160296477-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB BACE1 4769/4885APP 4260/4885ABL1 2939/4885
US-20210228501-A1 Formulation and Process for Modulating Wound Healing ATG7, SQSTM1, ATF4 BACE1 4804/4885APP 3850/4885ABL1 2536/4885
US-10426742-B2 Formulation and process for modulating wound healing SQSTM1, ATG7, TFEB BACE1 4779/4885APP 4010/4885ABL1 2543/4885
US-20190022029-A1 Formulation and Process for Modulating Wound Healing SQSTM1, ATG7, TFEB BACE1 4779/4885APP 4010/4885ABL1 2543/4885
US-11351126-B2 Substituted tolans for the modulation of microbial colonization LMAN1, DPM1, DSTN BACE1 3044/4885APP 3466/4885ABL1 1044/4885
US-20220296538-A1 Substituted Tolans for the Modulation of Microbial Colonization LMAN1, DPM1, DSTN BACE1 3044/4885APP 3466/4885ABL1 1044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.