Sugi Predict

Sugi Predict / Compounds / SCHEMBL6741260

SCHEMBL6741260

SCHEMBL6741260

O=Cc1ccc(Oc2cccc(F)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 0.49
▸ MAOB P27338 2/20 0.49
▸ ALDH1A1 P00352 5/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ PARP10 Q53GL7 1/20 0.46
▸ PARP3 Q9Y6F1 1/20 0.46
▸ MMP2 P08253 1/20 0.46
▸ MMP3 P08254 1/20 0.46
▸ MMP9 P14780 1/20 0.46
▸ MMP14 P50281 1/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ DRD1 P21728 1/20 0.44
▸ NFE2L2 Q16236 2/20 0.44
▸ RELA Q04206 1/20 0.44
▸ PGR P06401 1/20 0.43
▸ KCNH2 Q12809 1/20 0.43
▸ SCN3A Q9NY46 1/20 0.43
▸ CYP2A6 P11509 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2534036 0.87 MAOA (0.62) MAOAMAOBALDH1A1LMNANFE2L2
SCHEMBL8546955 0.87 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2KDM4ELMNAPARP10
SCHEMBL6290496 0.84 ALDH1A1 (0.54) MAOBALDH1A1SMN1; SMN2MMP2MMP3
SCHEMBL6289347 0.84 ALDH1A1 (0.54) MAOBALDH1A1SMN1; SMN2MMP2MMP3
SCHEMBL6142802 0.83 PARP10 (0.50) ALDH1A1SMN1; SMN2KDM4ELMNAPARP10
SCHEMBL6853633 0.83 SRC (0.53) MAOAMAOBALDH1A1SMN1; SMN2KDM4E
SCHEMBL8545768 0.83 PARP10 (0.50) ALDH1A1SMN1; SMN2KDM4ELMNAPARP10
SCHEMBL31599170 0.83 SRC (0.53) MAOAMAOBALDH1A1SMN1; SMN2KDM4E
SCHEMBL6293128 0.82 SMN1; SMN2 (0.58) MAOBALDH1A1SMN1; SMN2LMNAMMP2
SCHEMBL6290729 0.82 SMN1; SMN2 (0.58) MAOBALDH1A1SMN1; SMN2LMNAMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE38425-E1 ANTICONVULSANTS ADMINISTERED ORALLLY UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES, INC. (CA) 2004-02-10 — — US claimed
EP-0836591-B1 SEMICARBAZONES HAVING CNS ACTIVITY AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME UNIV SASKATCHEWAN (CA) 2001-09-26 — — EP claimed
CN-1062263-C Semicarbazones having CNS activity and pharmaceutical preparations containing same UNIV SASKATCHEWAN (CA) 2001-02-21 — — CN claimed
US-5741818-A ANTICONVULSANTS UNIVERSITY OF SASKATCHEWAN (CA) 1998-04-21 — — US claimed
EP-3762364-B1 PYRROLIDINEAMIDE DERIVATIVES AND USES THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2023-08-23 — — EP disclosed
US-11225460-B2 Pyrrolidineamide derivatives and uses thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2022-01-18 — — US disclosed
US-20210053918-A1 PYRROLIDINEAMIDE DERIVATIVES AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2021-02-25 — — US disclosed
CN-109890821-A Amino-pyrrolopyrimidine ketone compound and its application method 艾科尔公司 2019-06-14 — — CN disclosed
EP-2773352-B1 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS RES TRIANGLE INST (US) 2017-06-28 — — EP disclosed
US-9512105-B2 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists RESEARCH TRIANGLE INSTITUTE (US) 2016-12-06 — — US disclosed
US-9422240-B2 Partially saturated nitrogen-containing heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD (JP) 2016-08-23 — — US disclosed
US-9422240-B2 Partially saturated nitrogen-containing heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD (JP) 2016-08-23 — — US disclosed
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO., LTD (JP) 2015-06-25 — — US disclosed
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO., LTD (JP) 2015-06-25 — — US disclosed
US-20150005315-A1 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS RESEARCH TRIANGLE INSTITUTE (US) 2015-01-01 — — US disclosed
EP-2773352-A2 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS Research Triangle Institute, International (US) 2014-09-10 — — EP disclosed
WO-2013086496-A2 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS RESEARCH TRIANGLE INSTITUTE (US) 2013-06-13 — — WO disclosed
EP-0784612-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-23 — — EP disclosed
WO-1996010559-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-04-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND EGLN2, EGLN3, EGLN1 MAOA 837/4885MAOB 412/4885ALDH1A1 2293/4885
US-11225460-B2 Pyrrolidineamide derivatives and uses thereof MAOB, MAOA, PARK7 MAOA 2/4885MAOB 1/4885ALDH1A1 1191/4885
US-20150005315-A1 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS OPRK1, OPRM1, OPRD1 MAOA 643/4885MAOB 376/4885ALDH1A1 1610/4885
US-20210053918-A1 PYRROLIDINEAMIDE DERIVATIVES AND USES THEREOF MAOB, MAOA, PARK7 MAOA 2/4885MAOB 1/4885ALDH1A1 1191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.