Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 9/20 | 0.35 |
| ▸ | PPARA | Q07869 | 9/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961288 | 0.77 | TSHR (0.37) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL7661580 | 0.76 | LTA4H (0.39) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL4405391 | 0.74 | TSHR (0.33) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL11289603 | 0.73 | CHRM1 (0.37) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL8012067 | 0.73 | LTA4H (0.36) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL25261859 | 0.73 | LTA4H (0.36) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL7362599 | 0.73 | CA1 (0.37) | TSHRLTA4HPPARGPPARAMTNR1A | |
| SCHEMBL9353539 | 0.73 | MTNR1A (0.42) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL43675 | 0.73 | MTNR1A (0.42) | TSHRLTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL4963146 | 0.73 | MTNR1A (0.38) | TSHRLTA4HMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180066009-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | CHEMGENES CORP (US) | 2018-03-08 | — | — | US | claimed |
| US-20140350234-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | CHEMGENES CORPORATION (US) | 2014-11-27 | — | — | US | claimed |
| US-20040142946-A1 | Modified nucleosides and nucleotides and use thereof | CHATTOPADHYAYA JYOTI (SE) | 2004-07-22 | — | — | US | claimed |
| EP-1332150-A1 | MODIFIED NUCLEOSIDES AND NUCLEOTIDES AND USE THEREOF | Chattopadhyaya, Jyoti (SE) | 2003-08-06 | — | — | EP | claimed |
| WO-2002038578-A1 | MODIFIED NUCLEOSIDES AND NUCLEOTIDES AND USE THEREOF | CHATTOPADHYAYA JYOTI (SE) | 2002-05-16 | — | — | WO | claimed |
| US-5721350-A | Deuterated nucleosides | CHATTOPADHYAYA JYOTI (SE) | 1998-02-24 | — | — | US | claimed |
| EP-0648220-A1 | DEUTERATED NUCLEOSIDES | CHATTOPADHYAYA, Jyoti (SE) | 1995-04-19 | — | — | EP | claimed |
| WO-1993025566-A1 | DEUTERATED NUCLEOSIDES | CHATTOPADHYAYA JYOTI (SE) | 1993-12-23 | — | — | WO | claimed |
| US-3975532-A | ANALGESIC | ICI UNITED STATES INC. (US) | 1976-08-17 | — | — | US | claimed |
| EP-3478691-A1 | PRINS REACTION AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2019-05-08 | — | — | EP | disclosed |
| EP-3292130-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES | Eisai R&D Management Co., Ltd. (JP) | 2018-03-14 | — | — | EP | disclosed |
| WO-2018006031-A1 | PRINS REACTION AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-01-04 | — | — | WO | disclosed |
| WO-2016179607-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-10 | — | — | WO | disclosed |
| EP-3066102-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | Eisai R&D Management Co., Ltd. (JP) | 2016-09-14 | — | — | EP | disclosed |
| EP-0362902-A2 | Process and intermediates for beta-lactam antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1990-04-11 | — | — | EP | disclosed |
| EP-0241363-A1 | Nucleoside derivatives and their use in the synthesis of oligonucleotides | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1987-10-14 | — | — | EP | disclosed |
| EP-0234036-A1 | Use of amides for improving the tolerance of crops to herbicidally active sulfoxyl urea derivatives | BAYER AG (DE) | 1987-09-02 | — | — | EP | disclosed |
| US-4598079-A | MEMORY DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1986-07-01 | — | — | US | disclosed |
| US-3975532-A | ANALGESIC | ICI UNITED STATES INC. (US) | 1976-08-17 | — | — | US | disclosed |
| US-3723493-A | S-ACYL DERIVATIVES OF 3-MERCAPTO-2-CHLOROPROOPYL N,N-DIALKYLTHIOLCARBAMATES | CHEVRON RESEARCH COMPANY, SAN FRANCISCO, CA. A CORP. OF DE. | 1973-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142946-A1 | Modified nucleosides and nucleotides and use thereof | RNASEH1, RNASEL, NSUN2 | TSHR 1258/4885LTA4H 519/4885MEN1 4771/4885 |
| US-20140350234-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | UNG, OGG1, ADAR | TSHR 1132/4885LTA4H 1989/4885MEN1 2445/4885 |
| US-20180066009-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | UNG, OGG1, ADAR | TSHR 1132/4885LTA4H 1989/4885MEN1 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.