Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758205 | 0.81 | HRH3 (0.40) | L3MBTL1HRH3HRH4LMNAHRH1 | |
| SCHEMBL30041159 | 0.79 | HRH3 (0.38) | L3MBTL1HRH3HRH4LMNAHRH1 | |
| Hydrochloric Acid SCHEMBL5606847 | 0.75 | ALDH1A1 (0.38) | L3MBTL1LMNAALDH1A1ALOX15MAPT | |
| Hydrochloric Acid SCHEMBL27387860 | 0.73 | CYP11B1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL1072138 | 0.70 | LMNA (0.37) | HRH3HRH4LMNAHRH1ALDH1A1 | |
| SCHEMBL41191 | 0.69 | L3MBTL1 (0.59) | L3MBTL1HRH3HRH4LMNAHRH1 | |
| SCHEMBL29830938 | 0.69 | L3MBTL1 (0.59) | L3MBTL1HRH3HRH4LMNAHRH1 | |
| Hydrochloric Acid SCHEMBL27617899 | 0.68 | ALDH1A1 (0.42) | HRH3HRH4LMNAHRH1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1685844 | 0.68 | HRH1 (0.42) | HRH3HRH4LMNAHRH1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10884973 | 0.67 | L3MBTL1 (0.57) | L3MBTL1HRH3HRH4LMNAHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171857-A1 | Catalyst for the production of olefin polymers | WANG CHUNMING (US) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171857-A1 | Catalyst for the production of olefin polymers | PORCN, PPOX, YAP1 | L3MBTL1 3264/4885HRH3 3251/4885HRH4 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.