Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 6/20 | 0.52 |
| ▸ | MMP13 | P45452 | 6/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625903 | 0.85 | ADAM17 (0.58) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6502723 | 0.85 | ADAM17 (0.58) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6838293 | 0.81 | HRH3 (0.49) | MMP1MMP9MMP13HRH3KCNH2 | |
| SCHEMBL6501698 | 0.80 | CA12 (0.55) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6499387 | 0.79 | ADAM17 (0.59) | MMP1MMP9MMP13ADAM17HRH3 | |
| SCHEMBL6658476 | 0.79 | MMP1 (0.65) | MMP1MMP9MMP13ADAM17HRH3 | |
| SCHEMBL7236556 | 0.77 | HRH3 (0.51) | MMP1MMP9MMP13ADAM17HRH3 | |
| SCHEMBL3941876 | 0.76 | ADAM17 (0.73) | MMP1MMP9MMP13ADAM17HRH3 | |
| SCHEMBL2897169 | 0.75 | PSMB1 (0.60) | HRH3PSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL6657950 | 0.75 | MMP13 (0.80) | MMP1MMP9MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6812227-B2 | SULFUR COMPOUNDS SUCH AS 2-((4-BUT-2-YNYLOXY-BENZENESULFONYL)-METHYL-AMINO)-N-HYDROXY-3-METHYL -BUTYRAMIDE, USED AS TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) INHIBITORS, FOR PROPHYLAXIS OF RHEUMATIC DISEASES, SEPSIS OR INFLAMMATION | WYETH HOLDINGS CORPORATION | 2004-11-02 | — | — | US | disclosed |
| US-6716833-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS. | WYETH HOLDINGS CORPORATION | 2004-04-06 | — | — | US | disclosed |
| US-20030212049-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH (US) | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212049-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, TASP1 | MMP1 130/4885MMP9 137/4885MMP13 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.