Thiabendazole

Thiabendazole

SCHEMBL675655

O=PO.c1ccc2[nH]c(-c3cscn3)nc2c1

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP1 P53582 9/20 0.83
METAP2 P50579 7/20 0.83
NPC1 O15118 5/20 0.83
RAB9A P51151 5/20 0.83
SMN1; SMN2 Q16637 5/20 0.83
TP53 P04637 4/20 0.83
KDM4E B2RXH2 3/20 0.83
FKBP1A P62942 2/20 0.83
ADORA3 P0DMS8 2/20 0.83
TSHR P16473 2/20 0.83
CYP1A2 P05177 1/20 0.83
CYP3A4 P08684 1/20 0.83
CYP2D6 P10635 1/20 0.83
CYP2C19 P33261 1/20 0.83
HIF1A Q16665 1/20 0.83
TDP1 Q9NUW8 1/20 0.83
HDAC6 Q9UBN7 1/20 0.83
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiabendazole SCHEMBL30099775 1.00 METAP1 (0.83) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL19842 0.91 METAP1 (1.00) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL29370729 0.91 METAP1 (1.00) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL625588 0.91 METAP1 (1.00) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL7733801 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL2314460 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL28861440 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL9856779 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL11218788 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2
Thiabendazole SCHEMBL5184037 0.90 METAP1 (0.97) METAP1METAP2NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389424-B1 Aqueous dispersion with fungicidal and algicidal action AIR LIQUIDE SANTE INT (FR) 2006-02-15 EP claimed
US-20050101487-A1 Aqueous dispersion with fungicidal and algicidal action AIR LIQUIDE SANTE (INTERNATIONAL) (FR) 2005-05-12 US claimed
EP-1389424-A1 Aqueous dispersion with fungicidal and algicidal action Air Liquide Santé (International) (FR) 2004-02-18 EP claimed
US-12325646-B2 Fertigation water treatment UNIVERSITY OF GUELPH (CA) 2025-06-10 US disclosed
US-20250024837-A1 PESTICIDE SYSTEM BANISH, MICHELE 2025-01-23 US disclosed
US-20240074434-A1 COMPOSITION INCLUDING EFFERVESCENT AGENTS, BIOSTIMULANT, NUTRIENT, AND PESTICIDE ROBBINS JEFFREY HANSON (US) 2024-03-07 US disclosed
US-20240065262-A1 COMPOSITION INCLUDING EFFERVESCENT AGENTS, BIOSTIMULANT, NUTRIENT, AND PESTICIDE ROBBINS JEFFREY HANSON (US) 2024-02-29 US disclosed
WO-2023154183-A1 COMPOSITION INCLUDING EFFERVESCENT AGENTS, BIOSTIMULANT, NUTRIENT, AND PESTICIDE ROBBINS JEFFREY (US) 2023-08-17 WO disclosed
US-20230172194-A1 COMPOSITION INCLUDING EFFERVESCENT AGENTS, BIOSTIMULANT, NUTRIENT, AND PESTICIDE ROBBINS JEFFREY HANSON (US) 2023-06-08 US disclosed
US-20220272987-A1 COMPOSITION INCLUDING EFFERVESCENT AGENTS, BIOSTIMULANT, NUTRIENT, AND PESTICIDE ROBBINS JEFFREY H (US) 2022-09-01 US disclosed
US-20220234916-A1 WATER TREATMENT UNIVERSITY OF GUELPH (CA) 2022-07-28 US disclosed
US-20110274677-A1 Biological Pest Control Mixture Containing D-Limonene and Nutmeg Oil MULLEN BOB 2011-11-10 US disclosed
WO-2009135289-A1 BIOLOGICAL PEST CONTROL MIXTURE CONTAINING D-LIMONENE AND NUTMEG OIL MULLEN BOB (CA) 2009-11-12 WO disclosed
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2006-12-07 US disclosed
EP-1389424-B1 Aqueous dispersion with fungicidal and algicidal action AIR LIQUIDE SANTE INT (FR) 2006-02-15 EP disclosed
US-20050101487-A1 Aqueous dispersion with fungicidal and algicidal action AIR LIQUIDE SANTE (INTERNATIONAL) (FR) 2005-05-12 US disclosed
EP-1389424-A1 Aqueous dispersion with fungicidal and algicidal action Air Liquide Santé (International) (FR) 2004-02-18 EP disclosed
US-6528114-B1 Waterproof coating, to a wood surface using a collapsing foam coating material. The material is initially sprayed onto a recessed wood surface, whereupon the resin material foams and collapses over a relatively short period of time into a film SASHCO, INC. 2003-03-04 US disclosed
US-5224967-A Multilayer wraps with backings and matrix LEC TEC CORPORATION (US) 1993-07-06 US disclosed
US-5142817-A Flexible polymeric sheet backing, homogeneous hydrophilic tacky matrix on backing which includes nonaqueous polar water-miscible plasticizing liquid, water-soluble or swellable polymer, biologically active protective composition LEC TEC CORPORATION (US) 1992-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients ENPP1, ENPP3, SMPD1 METAP1 359/4885METAP2 426/4885NPC1 2183/4885
US-20250024837-A1 PESTICIDE SYSTEM ACHE, PFAS, FPGS METAP1 2823/4885METAP2 1657/4885NPC1 4883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.