Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760652 | 0.96 | NAMPT (0.42) | NAMPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6948898 | 0.89 | MAOB (0.36) | NAMPTMAOBLDHANTRK3NTRK2 | |
| SCHEMBL5444456 | 0.81 | NAMPT (0.41) | NAMPTALDH1A1SMN1; SMN2HPGDNTRK3 | |
| SCHEMBL5189062 | 0.81 | NAMPT (0.41) | NAMPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5236831 | 0.77 | L3MBTL1 (0.42) | NAMPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL16931551 | 0.77 | CDK5 (0.36) | NAMPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7371057 | 0.77 | BRD4 (0.44) | ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10 | |
| SCHEMBL6762800 | 0.76 | GFER (0.36) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL6948730 | 0.75 | ALDH1A1 (0.36) | NAMPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5238254 | 0.75 | POLB (0.48) | SMN1; SMN2MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030838-B1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | PFIZER PROD INC (US) | 2003-01-22 | — | — | EP | claimed |
| US-6262272-B1 | REACTING FURAN CARBOXYLIC ACID DERIVATIVE WITH ACID CHLORIDE OR ACID ANHYDRIDE IN INERT SOLVENT CONTAINING ACID RECEPTOR; ADDING AROMATIC AMINE COMPOUND TO FORM PYRROLE CARBOXAMIDE COMPOUND | PFIZER INC | 2001-07-17 | — | — | US | claimed |
| EP-1030838-A1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | Pfizer Products Inc. (US) | 2000-08-30 | — | — | EP | claimed |
| WO-1999025684-A1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | PFIZER PRODUCTS INC. (US) | 1999-05-27 | — | — | WO | claimed |
| US-20040220253-A1 | Synthesis of pyrrole amides | PFIZER INC. | 2004-11-04 | — | — | US | disclosed |
| EP-1339681-A1 | SYNTHESIS OF FUSED PYRROLECARBOXAMIDES | Pfizer Products Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-1030838-B1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | PFIZER PROD INC (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20020151718-A1 | Synthesis of pyrrole amides | PFIZER INC. | 2002-10-17 | — | — | US | disclosed |
| WO-2002046155-A1 | SYNTHESIS OF FUSED PYRROLECARBOXAMIDES | PFIZER PRODUCTS INC. (US) | 2002-06-13 | — | — | WO | disclosed |
| US-6262272-B1 | REACTING FURAN CARBOXYLIC ACID DERIVATIVE WITH ACID CHLORIDE OR ACID ANHYDRIDE IN INERT SOLVENT CONTAINING ACID RECEPTOR; ADDING AROMATIC AMINE COMPOUND TO FORM PYRROLE CARBOXAMIDE COMPOUND | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| EP-1030838-A1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | Pfizer Products Inc. (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999025684-A1 | METHOD OF SYNTHESIS OF PYRROLE AMIDES | PFIZER PRODUCTS INC. (US) | 1999-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220253-A1 | Synthesis of pyrrole amides | GABRA5, GABRA2, GABRA1 | NAMPT 3853/4885ALDH1A1 390/4885SMN1; SMN2 4719/4885 |
| US-20020151718-A1 | Synthesis of pyrrole amides | GABRA5, GABRA2, GABRA1 | NAMPT 3853/4885ALDH1A1 390/4885SMN1; SMN2 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.