Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23073315 | 0.83 | CYP3A4 (0.45) | LMNAHIF1AADRA2AADRA2CKDM4E | |
| SCHEMBL640127 | 0.83 | GABRA1 (0.54) | LMNAHIF1AKDM4EALDH1A1GABRA1 | |
| SCHEMBL20256365 | 0.81 | CES2 (0.48) | ALDH1A1CYP3A4SLC6A2 | |
| SCHEMBL1669099 | 0.81 | ESR1 (0.50) | LMNAHIF1AADRA2AADRA2CKDM4E | |
| Bromide SCHEMBL209321 | 0.81 | GABRA1 (0.52) | LMNAHIF1AADRA2AADRA2CKDM4E | |
| SCHEMBL12232405 | 0.77 | NOS3 (0.36) | LMNAHIF1AADRA2AADRA2CKDM4E | |
| SCHEMBL14349091 | 0.77 | NOS3 (0.36) | LMNAHIF1AADRA2AADRA2CKDM4E | |
| SCHEMBL5141202 | 0.77 | ALDH1A1 (0.56) | ADRA2AADRA2CALDH1A1AOC3TSHR | |
| SCHEMBL3131040 | 0.75 | TSHR (0.41) | ADRA2AKDM4EALDH1A1TSHRCA1 | |
| SCHEMBL18929401 | 0.75 | ALDH1A1 (0.46) | LMNAHIF1AADRA2AADRA2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173408-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | Taisho Pharmaceutical Co., Ltd. (JP) | 2017-05-31 | — | — | EP | disclosed |
| US-6750343-B2 | REACTING A 5- AND 6- HALOMETHYL QUINOXALINE WITH A WATER-SOLUBLE NUCLEOPHILE, DEHALOGENATION, DECHLORINATION, DEBROMINATION, HYDROXYLATION; CHEMICAL INTERMEDIATES FOR PHARMACEUTICAL COMPOUNDS | AIR PRODUCTS AND CHEMICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-20030166934-A1 | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines | BURDENIUC JUAN JESUS (US) | 2003-09-04 | — | — | US | disclosed |
| US-20030158411-A1 | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines | BURDENIUC JUAN JESUS (US) | 2003-08-21 | — | — | US | disclosed |
| US-6548670-B1 | Reacting chloro(or bromo)alkylquinoxaline with nucleophilic compound in presence of phase transfer catalyst to make hydroxyalkylquinoxaline; debromination, dechlorination, hydroxylation | AIR PRODUCTS AND CHEMICALS, INC. | 2003-04-15 | — | — | US | disclosed |
| EP-1279668-A1 | Methods for preparing 5- and 6-benzyl functionalized quinoxalines | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2003-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166934-A1 | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines | NUDT1, ALKBH5, INMT | LMNA 1762/4885HIF1A 3987/4885ADRA2A 2156/4885 |
| US-20030158411-A1 | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines | NUDT1, ALKBH5, INMT | LMNA 1762/4885HIF1A 3987/4885ADRA2A 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.