SCHEMBL676794

SCHEMBL676794

COC=C(C(=O)OC)c1ccccc1CON=C(C)c1cccc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.46
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
TP53 P04637 1/20 0.40
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
RXFP1 Q9HBX9 3/20 0.40
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23972131 1.00 HIF1A (0.46) HIF1AKMT2AMEN1TP53PPARG
SCHEMBL19342159 1.00 HIF1A (0.46) HIF1AKMT2AMEN1TP53PPARG
SCHEMBL10014844 1.00 HIF1A (0.46) HIF1AKMT2AMEN1TP53PPARG
SCHEMBL6032705 1.00 HIF1A (0.46) HIF1AKMT2AMEN1TP53PPARG
SCHEMBL8230371 0.88 NPSR1 (0.41) HIF1AKMT2AMEN1PPARGPPARA
SCHEMBL23969503 0.87 KMT2A (0.42) HIF1AKMT2AMEN1PPARGPPARA
SCHEMBL25552199 0.86 HIF1A (0.48) HIF1APPARGPPARA
Picoxystrobin SCHEMBL7203031 0.86 HIF1A (0.51) HIF1AKMT2AMEN1PPARGPPARA
SCHEMBL9892568 0.85 HIF1A (0.48) HIF1AKMT2AMEN1TP53PPARG
SCHEMBL12635931 0.85 HIF1A (0.64) HIF1AKMT2AMEN1TP53PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8410021-B2 Compositions for the control of plant pests BAYER CROPSCIENCE AG (DE) 2013-04-02 US disclosed
US-8153665-B2 Agents for controlling plant pests BAYER AKTIENGESELLSCHAFT (DE) 2012-04-10 US disclosed
US-7884049-B2 A synergistic mixture of imidacloprid and metalaxyl and does not contain thiram or fludioxonil; pesticides; fungicides; insecticides; plant diseases BAYER CROPSCIENCE AG (DE) 2011-02-08 US disclosed
US-7868025-B2 Pesticide BAYER CROPSCIENCE AG (DE) 2011-01-11 US disclosed
US-20100305170-A1 Agents for Combating Plant Pests BAYER CROPSCIENCE AG (DE) 2010-12-02 US disclosed
US-20100210691-A1 Compositions for the Control of Plant Pests BAYER CROPSCIENCE AG (DE) 2010-08-19 US disclosed
US-7763266-B2 Agents for combating plant pests BAYER CROPSCIENCE AG (DE) 2010-07-27 US disclosed
US-7696237-B2 Agents for combating plant pests BAYER CROPSCIENCE AG (DE) 2010-04-13 US disclosed
US-20100041659-A1 Compositions for the control of plant pests BAYER INTELLECTUAL PROPERTY GMBH (DE) 2010-02-18 US disclosed
US-20090170912-A1 AGENTS FOR COMBATING PLANT PESTS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2009-07-02 US disclosed
US-20040204405-A1 Thiazines and thiazoles as agents for protecting materials LANXESS DEUTSCHLAND GMBH (DE) 2004-10-14 US disclosed
US-20030207929-A1 3-nitroisoxazoles and their use in the protection of materials LANXESS DEUTSCHLAND GMBH (DE) 2003-11-06 US disclosed
US-20030166698-A1 3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS LANXESS DEUTSCHLAND GMBH (DE) 2003-09-04 US disclosed
EP-0982995-B1 ALGICIDES BAYER AG (DE) 2003-08-20 EP disclosed
US-20030129081-A1 Thiazines and thiazoles as agents for protecting materials BAYER AKTIENGESELLSCHAFT (DE) 2003-07-10 US disclosed
US-6531496-B1 Pesticides in crop protection BAYER AKTIENGESELLSCHAFT (DE) 2003-03-11 US disclosed
US-20030040540-A1 For use as biocides for protecting plants and industrial materials BAYER AKTIENGESELLSCHAFT (DE) 2003-02-27 US disclosed
US-6075019-A Arylthio-dithiazindioxides and their use as pesticides BAYER AKTIENGESELLSCHAFT (DE) 2000-06-13 US disclosed
EP-0975611-A1 3-ALKOXY ISOTHIAZOLES BAYER AG (DE) 2000-02-02 EP disclosed
WO-1998042689-A1 3-ALKOXY ISOTHIAZOLES BAYER AKTIENGESELLSCHAFT (DE) 1998-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030129081-A1 Thiazines and thiazoles as agents for protecting materials POT1, NAT1, GPX1 HIF1A 2331/4885KMT2A 4152/4885MEN1 97/4885
US-20040204405-A1 Thiazines and thiazoles as agents for protecting materials POT1, NAT1, GPX1 HIF1A 2331/4885KMT2A 4152/4885MEN1 97/4885
US-20100305170-A1 Agents for Combating Plant Pests DDT, CYP51A1, AADAC HIF1A 4126/4885KMT2A 1158/4885MEN1 3203/4885
US-20100210691-A1 Compositions for the Control of Plant Pests MLX, CNPY3, PRDX2 HIF1A 4876/4885KMT2A 756/4885MEN1 2948/4885
US-20100041659-A1 Compositions for the control of plant pests RDX, PRXL2A, ACHE HIF1A 4694/4885KMT2A 1132/4885MEN1 3480/4885
US-20030040540-A1 For use as biocides for protecting plants and industrial materials BROX, GPX1, PRDX3 HIF1A 2185/4885KMT2A 3890/4885MEN1 3505/4885
US-20090170912-A1 AGENTS FOR COMBATING PLANT PESTS DDT, CYP51A1, ACHE HIF1A 4668/4885KMT2A 2439/4885MEN1 2385/4885
US-20030166698-A1 3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS GPX1, NOX1, XDH HIF1A 541/4885KMT2A 3492/4885MEN1 1505/4885
US-20030207929-A1 3-nitroisoxazoles and their use in the protection of materials GPX1, NOX1, XDH HIF1A 541/4885KMT2A 3492/4885MEN1 1505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.