Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL2281423 | 0.80 | LMNA (0.39) | NPC1PTGDR2GPR183ACACBTSHR | |
| SCHEMBL2636129 | 0.80 | TSHR (0.44) | PTGDR2CES2CES1GPR183ACACB | |
| SCHEMBL8443823 | 0.80 | KCNH2 (0.42) | PTGDR2CES2CES1GPR183ACACB | |
| SCHEMBL6574954 | 0.80 | APP (0.52) | NPC1LMNAMAPTHTTALOX15 | |
| SCHEMBL10794117 | 0.78 | TSHR (0.43) | PTGDR2CES2CES1GPR183ACACB | |
| SCHEMBL21066942 | 0.78 | GPR183 (0.40) | CES2CES1GPR183ACACBLMNA | |
| SCHEMBL6776577 | 0.78 | APP (0.49) | NPC1CES2CES1GPR183ALDH1A1 | |
| SCHEMBL4487823 | 0.78 | ACACB (0.46) | PTGDR2CES2CES1GPR183ACACB | |
| SCHEMBL6781061 | 0.78 | VCP (0.52) | CES2CES1ACACBLMNAGSK3B | |
| SCHEMBL3696839 | 0.77 | NPSR1 (0.55) | NPC1MAPTHTTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274246-A1 | AMIDE COMPOUND AND USE THEREOF | 成都分迪药业有限公司 | 2023-01-05 | — | — | WO | disclosed |
| US-20190192524-A1 | Modulators of Caspase-6 | UNIVERSITY OF HAMBURG (DE) | 2019-06-27 | — | — | US | disclosed |
| EP-3129027-A1 | MODULATORS OF CASPASE-6 | University of British Columbia (CA) | 2017-02-15 | — | — | EP | disclosed |
| WO-2016020732-A1 | MODULATORS OF CASPASE-6 | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2016-02-11 | — | — | WO | disclosed |
| US-6767906-B2 | INHIBIT P34CDC2/CYCLIN BCDC13 KINASE AND PROTEIN TYROSINE KINASE PP60C-SRC AND CAN BE USED FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES, FOR EXAMPLE CHEMOTHERAPY OF TUMOURS OR OSTEOPOROSIS. | NOVARTIS AG (CH) | 2004-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192524-A1 | Modulators of Caspase-6 | CASP6, CASP10, CASP2 | NPC1 1977/4885PTGDR2 3574/4885CES2 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.