Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 5/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772036 | 0.92 | CCR2 (0.41) | CTRB1F10ICMTCCR2PLA2G2A | |
| SCHEMBL6770631 | 0.89 | PLA2G2A (0.46) | F10PLA2G10PLA2G2APLA2G1BFAAH | |
| SCHEMBL6694433 | 0.89 | PLA2G2A (0.46) | PLA2G10PLA2G2APLA2G1BPARP1 | |
| SCHEMBL6770697 | 0.89 | F10 (0.46) | CTRB1F10PLA2G10ICMTCCR2 | |
| SCHEMBL6782681 | 0.88 | ICMT (0.41) | CTRB1F10PLA2G10ICMTCCR2 | |
| SCHEMBL6894708 | 0.87 | SLC6A2 (0.41) | F10CCR2PLA2G2A | |
| SCHEMBL6777431 | 0.87 | PARP1 (0.41) | CTRB1F10PLA2G10ICMTCCR2 | |
| SCHEMBL6774933 | 0.86 | PLA2G2A (0.42) | F10PLA2G10PLA2G2APLA2G1B | |
| SCHEMBL6770280 | 0.86 | PLA2G2A (0.40) | PLA2G10ICMTPLA2G2APLA2G1BFAAH | |
| SCHEMBL6778086 | 0.86 | F10 (0.40) | CTRB1F10PLA2G10ICMTCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |