Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775883 | 0.92 | CTRB1 (0.41) | CCR2F10PLA2G2AICMTCTRB1 | |
| SCHEMBL6690216 | 0.90 | PLA2G2A (0.43) | CCR2PLA2G2APPARGIKBKBCHUK | |
| SCHEMBL6776773 | 0.88 | PLA2G2A (0.42) | CCR2PLA2G2APPARG | |
| SCHEMBL6776758 | 0.88 | PLA2G2A (0.50) | CCR2F10PLA2G2A | |
| SCHEMBL6891577 | 0.88 | DRD2 (0.47) | CCR2PPARGDRD2TBXA2R | |
| SCHEMBL6771677 | 0.86 | PLA2G2A (0.41) | CCR2PLA2G2APPARGCNR2 | |
| SCHEMBL6774857 | 0.86 | FAAH (0.43) | CCR2PLA2G2AICMTPPARG | |
| SCHEMBL7963393 | 0.86 | PLA2G2A (0.47) | PLA2G2A | |
| SCHEMBL6770697 | 0.86 | F10 (0.46) | CCR2F10PLA2G2AICMTCTRB1 | |
| SCHEMBL6772770 | 0.85 | PLA2G2A (0.41) | F10PLA2G2AICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |