Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 10/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.42 |
| ▸ | ITGAV | P06756 | 9/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.39 |
| ▸ | MDM4 | O15151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775970 | 0.92 | GPR132 (0.49) | ITGB1ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL6773776 | 0.91 | CTSB (0.43) | FPR2ITGB1ITGB3ITGAVGPR132 | |
| SCHEMBL7823171 | 0.91 | ITGB3 (0.50) | ITGB1ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7340124 | 0.90 | CA2 (0.46) | ITGB1ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7345088 | 0.89 | ITGB3 (0.41) | ITGB1ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7340345 | 0.88 | TP53 (0.39) | ITGB1ITGB3ITGAVITGA5MDM2 | |
| SCHEMBL7837213 | 0.88 | CTSL (0.41) | ITGB1ITGB3ITGAVGPR132ITGA5 | |
| SCHEMBL3051751 | 0.87 | GPR139 (0.44) | ITGB1ITGB3ITGAVITGB5GPR132 | |
| SCHEMBL7345869 | 0.87 | HTT (0.43) | ITGB1ITGB3ITGAVITGB5ITGA5 | |
| SCHEMBL6778084 | 0.87 | GPR139 (0.45) | FPR2ITGB1ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |