Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.39 |
| ▸ | ITGAV | P06756 | 7/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.39 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782093 | 0.90 | ITGB1 (0.41) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL7339213 | 0.89 | MEN1 (0.46) | HTTKDM4ELMNAMAPTITGB3 | |
| SCHEMBL7834854 | 0.88 | GPR139 (0.42) | HTTKDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6779571 | 0.87 | FPR2 (0.43) | ITGB3ITGAVITGB1ITGA5ITGB5 | |
| SCHEMBL6773776 | 0.86 | CTSB (0.43) | HTTKDM4ELMNAMAPTITGB3 | |
| SCHEMBL7345088 | 0.84 | ITGB3 (0.41) | HTTKDM4ELMNAMAPTITGB3 | |
| SCHEMBL6779870 | 0.83 | ITGB3 (0.45) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL7345759 | 0.83 | ITGB3 (0.56) | HTTKDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6775970 | 0.83 | GPR132 (0.49) | ITGB3ITGAVITGB1ITGA5ITGB5 | |
| SCHEMBL7344536 | 0.83 | POLB (0.39) | ITGB3ITGAVITGB1ITGA5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |