SCHEMBL6784892

SCHEMBL6784892

COc1cc(C(F)(F)C(=O)N2C3CCCC2C(=O)N(CC(CCCc2ccccc2)CCCc2ccccc2)C3)cc(OC)c1OC

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 12/20 0.48
FKBP5 Q13451 2/20 0.43
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6781032 0.94 FKBP1A (0.47) FKBP1AFKBP5ALDH1A1
SCHEMBL6776757 0.86 FKBP1A (0.47) FKBP1AFKBP5ALDH1A1
SCHEMBL6779072 0.82 FKBP5 (0.54) FKBP1AFKBP5ALDH1A1
SCHEMBL6785000 0.79 FKBP1A (0.45) FKBP1AFKBP5ALDH1A1
SCHEMBL6779125 0.79 FKBP1A (0.44) FKBP1AFKBP5
SCHEMBL6780351 0.78 KMT2A (0.40) FKBP1A
SCHEMBL6774588 0.77 FKBP5 (0.47) FKBP1AFKBP5ALDH1A1
SCHEMBL6783532 0.76 FKBP5 (0.47) FKBP1AFKBP5ALDH1A1
SCHEMBL6776517 0.76 FKBP5 (0.45) FKBP1AFKBP5ALDH1A1
SCHEMBL6774415 0.75 BCHE (0.39) FKBP1AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6818643-B1 3,9-DIAZABICYCLO(3.3.1)NONAN-2-ONE DERIVATIVES; PEPTIDYL-PROLYL ISOMERASE (PPIASE OR ROTAMASE) INHIBITORS; NEUROPROTECTIVE AGENTS BRISTOL-MYERS SQUIBB COMPANY 2004-11-16 US disclosed