Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776757 | 0.85 | FKBP1A (0.47) | FKBP1AALDH1A1KMT2AMAPTFKBP5 | |
| SCHEMBL6781032 | 0.82 | FKBP1A (0.47) | FKBP1AALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL6784892 | 0.79 | FKBP1A (0.48) | FKBP1AALDH1A1FKBP5 | |
| SCHEMBL6783532 | 0.75 | FKBP5 (0.47) | FKBP1AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6779072 | 0.71 | FKBP5 (0.54) | FKBP1AALDH1A1KMT2AFKBP5 | |
| SCHEMBL6780693 | 0.67 | SIGMAR1 (0.42) | ALDH1A1KMT2AMEN1SIGMAR1 | |
| SCHEMBL6779167 | 0.66 | SIGMAR1 (0.46) | FKBP1AALDH1A1SIGMAR1 | |
| SCHEMBL6774415 | 0.61 | BCHE (0.39) | FKBP1AALDH1A1KMT2AMEN1G6PD | |
| SCHEMBL6628799 | 0.61 | FKBP5 (0.69) | FKBP1AALDH1A1FKBP5 | |
| SCHEMBL6627612 | 0.61 | FKBP1A (0.57) | FKBP1AFKBP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818643-B1 | 3,9-DIAZABICYCLO(3.3.1)NONAN-2-ONE DERIVATIVES; PEPTIDYL-PROLYL ISOMERASE (PPIASE OR ROTAMASE) INHIBITORS; NEUROPROTECTIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-16 | — | — | US | disclosed |