SCHEMBL6789084

SCHEMBL6789084

O=C(O)Nc1cccc(CCOc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SMO Q99835 1/20 0.48
MTTP P55157 12/20 0.46
APOB P04114 9/20 0.46
UGCG Q16739 1/20 0.45
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
OPRL1 P41146 1/20 0.43
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA4 P43681 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7133280 0.91 SORT1 (0.43) SMOMTTPAPOBUGCGOPRL1
SCHEMBL6500853 0.90 CHRNB2 (0.42) SMOMTTPAPOBOPRL1CHRNB2
SCHEMBL6789234 0.89 SMO (0.47) SMOMTTPAPOBUGCGPOLB
SCHEMBL6795238 0.88 SMO (0.47) SMOMTTPAPOBUGCGPOLB
Hydrochloric Acid SCHEMBL6801596 0.87 SMO (0.47) SMOMTTPAPOBUGCGPOLB
SCHEMBL6793327 0.86 SMO (0.59) SMOMTTPAPOBPOLBGAA
SCHEMBL7139254 0.85 LMNA (0.50) SMOMTTPAPOB
SCHEMBL6795217 0.83 SMO (0.47) SMOMTTPAPOBUGCGPOLB
SCHEMBL6799168 0.83 TP53 (0.49) SMOMTTPAPOBUGCGPOLB
SCHEMBL6492604 0.82 MTTP (0.42) SMOMTTPAPOBPOLBOPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 SMO 2094/4885MTTP 363/4885APOB 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.