SCHEMBL6793989

SCHEMBL6793989

O=C(Nc1ccc(C(O)c2ccccn2)cc1)c1cc(C(F)(F)F)ccc1-c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 5/20 0.48
SMO Q99835 1/20 0.43
JAK2 O60674 1/20 0.43
JAK1 P23458 1/20 0.43
TYK2 P29597 1/20 0.43
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
SORT1 Q99523 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
ALDH1A1 P00352 1/20 0.41
S1PR1 P21453 2/20 0.41
S1PR3 Q99500 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7083630 0.79 TUBB4A (0.53) TRPV1SMONPC1RAB9AALDH1A1
SCHEMBL7083634 0.79 TUBB4A (0.53) TRPV1SMONPC1RAB9AALDH1A1
SCHEMBL7086631 0.79 NPC1 (0.54) SMN1; SMN2NPC1RAB9A
SCHEMBL7133291 0.78 NPC1 (0.56) TRPV1KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL6792746 0.78 PTGS1 (0.57) SMN1; SMN2NPC1RAB9A
SCHEMBL7087226 0.77 SMO (0.49) TRPV1SMOSORT1EGLN1ALDH1A1
SCHEMBL7084038 0.77 NTRK1 (0.43) SMOSORT1ALDH1A1
SCHEMBL7080705 0.76 SMO (0.49) TRPV1SMOGAASORT1EGLN1
SCHEMBL7087379 0.76 RXFP1 (0.57) TRPV1SMN1; SMN2NPC1RAB9A
SCHEMBL7079809 0.75 CHRNB2 (0.45) TRPV1SMOEGLN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 TRPV1 3714/4885SMO 2094/4885JAK2 2198/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.