Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 6/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | DRD3 | P35462 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986354 | 0.84 | DRD2 (0.38) | THRATHRBDRD2DRD3DRD4 | |
| SCHEMBL3986226 | 0.76 | F2 (0.39) | RARGCTNNB1MEN1KMT2ANPSR1 | |
| SCHEMBL3993919 | 0.74 | RARG (0.31) | RARG | |
| SCHEMBL3985034 | 0.70 | RARG (0.36) | RARGCTNNB1MEN1KMT2ACYP1A2 | |
| SCHEMBL26740106 | 0.68 | THRA (0.41) | RENTHRATHRBCYP3A4KMT2A | |
| SCHEMBL3987889 | 0.67 | OPRD1 (0.50) | MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL3987891 | 0.67 | KMT2A (0.49) | MEN1KMT2A | |
| SCHEMBL1464757 | 0.67 | HSD11B1 (0.38) | THRATHRBMEN1KMT2ACYP2C19 | |
| SCHEMBL5880935 | 0.66 | PYGL (0.49) | CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25310429 | 0.66 | MAPT (0.40) | RENTHRATHRBCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224960-A1 | Pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224960-A1 | Pharmaceutical compositions and methods for their use | CYP3A5, CYP3A7, CYP3A43 | RARG 3032/4885CTNNB1 4070/4885REN 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.