Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5683015 | 0.98 | CHKA (0.50) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| SCHEMBL3447497 | 0.97 | ALDH1A1 (0.48) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL3446376 | 0.95 | LMNA (0.47) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| Iodide SCHEMBL7861647 | 0.95 | LMNA (0.47) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| Bromide SCHEMBL9328651 | 0.84 | CHRM2 (0.42) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| SCHEMBL13061797 | 0.82 | MEN1 (0.52) | ALDH1A1LMNACYP3A4HSD17B10HTT | |
| SCHEMBL9834890 | 0.82 | CHRM2 (0.40) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| Bromide SCHEMBL9330064 | 0.81 | KMT2A (0.39) | CHKAALDH1A1LMNACYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL6687261 | 0.81 | CHRM2 (0.40) | ALDH1A1LMNACYP3A4HSD17B10HTT | |
| Iodide SCHEMBL5455905 | 0.80 | HTT (0.53) | ALDH1A1LMNACYP3A4HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186318-A1 | Method for producing (2e)-2-(hydroxyphenyl-2-(alkoxyimino)-n-methylacetamides | BAYER CROPSCIENCE AG (DE) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186318-A1 | Method for producing (2e)-2-(hydroxyphenyl-2-(alkoxyimino)-n-methylacetamides | HMOX2, CYP1A2, PTGS2 | CHKA 3596/4885ALDH1A1 143/4885LMNA 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.