Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 10/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805765 | 0.88 | PARP1 (0.50) | PARP1 | |
| SCHEMBL6584637 | 0.79 | PARP1 (0.39) | KDM4EALDH1A1GAARXFP1NPSR1 | |
| SCHEMBL6806330 | 0.74 | MEN1 (0.60) | KDM4EALDH1A1NPSR1BTKPARP1 | |
| SCHEMBL6805412 | 0.68 | MAPK14 (0.46) | KDM4EALDH1A1GAAPARP1MAPT | |
| SCHEMBL6802033 | 0.67 | FGFR1 (0.51) | KDM4EALDH1A1NPSR1PARP1MAPT | |
| SCHEMBL17048129 | 0.67 | KDM4E (0.56) | KDM4EALDH1A1GAANPSR1BTK | |
| SCHEMBL6806949 | 0.67 | KDM4E (0.59) | KDM4EALDH1A1PARP1HTTMAPT | |
| SCHEMBL6805760 | 0.66 | PARP1 (0.51) | PARP1 | |
| SCHEMBL27461815 | 0.65 | KDM4E (0.54) | KDM4EALDH1A1GAANPSR1BTK | |
| SCHEMBL6803965 | 0.65 | EPHX2 (0.55) | BTKPARP1KDRPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |