Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.47 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.47 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29749825 | 1.00 | PDK1 (0.58) | PDK1CYP19A1ALDH1A1HSPB1MEN1 | |
| SCHEMBL6575768 | 0.87 | ALDH1A1 (0.50) | PDK1ALDH1A1HSPB1MEN1KMT2A | |
| SCHEMBL9501627 | 0.87 | ALDH1A1 (0.50) | PDK1ALDH1A1HSPB1MEN1KMT2A | |
| SCHEMBL9638881 | 0.87 | ALDH1A1 (0.50) | PDK1ALDH1A1HSPB1MEN1KMT2A | |
| SCHEMBL11835883 | 0.86 | CYP19A1 (0.61) | PDK1CYP19A1ALDH1A1MEN1KMT2A | |
| SCHEMBL11583868 | 0.84 | XDH (0.49) | PDK1CYP19A1ALDH1A1HSPB1MEN1 | |
| SCHEMBL3586660 | 0.83 | TTR (0.55) | PDK1ALDH1A1HSPB1MEN1KMT2A | |
| SCHEMBL7824974 | 0.83 | TTR (0.55) | PDK1ALDH1A1HSPB1MEN1KMT2A | |
| SCHEMBL11440349 | 0.83 | ALDH1A1 (0.56) | PDK1CYP19A1ALDH1A1MEN1KMT2A | |
| SCHEMBL8798263 | 0.83 | PDK1 (0.58) | PDK1ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354306-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-11-12 | — | — | US | claimed |
| US-20160207873-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | YALE UNIVERSITY (US) | 2016-07-21 | — | — | US | claimed |
| WO-2015031598-A2 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | YALE UNIVERSITY (US) | 2015-03-05 | — | — | WO | claimed |
| US-20040133046-A1 | Continuous process for preparing alkoxynitroarenes | ORBITAL ATK, INC. | 2004-07-08 | — | — | US | claimed |
| US-12168639-B2 | Therapeutic DNP derivatives and methods using same | YALE UNIVERSITY (US) | 2024-12-17 | — | — | US | disclosed |
| US-20240018089-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | UNIV YALE (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018089-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | UNIV YALE (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018089-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | UNIV YALE (US) | 2024-01-18 | — | — | US | disclosed |
| US-11597697-B2 | Therapeutic DNP derivatives and methods using same | YALE UNIVERSITY (US) | 2023-03-07 | — | — | US | disclosed |
| US-11472764-B2 | Therapeutic DNP derivatives and methods using same | YALE UNIVERSITY (US) | 2022-10-18 | — | — | US | disclosed |
| US-20220234989-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | UNIV YALE (US) | 2022-07-28 | — | — | US | disclosed |
| US-20200354306-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-11-12 | — | — | US | disclosed |
| WO-2015031598-A2 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | YALE UNIVERSITY (US) | 2015-03-05 | — | — | WO | disclosed |
| WO-2015031598-A2 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | YALE UNIVERSITY (US) | 2015-03-05 | — | — | WO | disclosed |
| US-20040133046-A1 | Continuous process for preparing alkoxynitroarenes | ORBITAL ATK, INC. | 2004-07-08 | — | — | US | disclosed |
| US-20040133046-A1 | Continuous process for preparing alkoxynitroarenes | ORBITAL ATK, INC. | 2004-07-08 | — | — | US | disclosed |
| EP-1097918-A1 | PROCESS FOR PRODUCING 4-SUBSTITUTED-2-NITRO-FLUOROBENZENES | MEIJI SEIKA KAISHA LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |
| EP-0328968-B1 | PROCESS FOR THE PREPARATION OF 4-ACYLAMINO-2-AMINO ALKOXY BENZENES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-05-12 | — | — | EP | disclosed |
| US-5047586-A | Process for the preparation of 4-acylamino-2-aminoalkoxybenzenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-09-10 | — | — | US | disclosed |
| EP-0328968-A2 | Process for the preparation of 4-acylamino-2-amino alkoxy benzenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018089-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
| US-11472764-B2 | Therapeutic DNP derivatives and methods using same | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
| US-20160207873-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | DNPEP, NPPA, DNPH1 | PDK1 130/4885CYP19A1 446/4885ALDH1A1 524/4885 |
| US-12168639-B2 | Therapeutic DNP derivatives and methods using same | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
| US-11597697-B2 | Therapeutic DNP derivatives and methods using same | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
| US-20200354306-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
| US-20040133046-A1 | Continuous process for preparing alkoxynitroarenes | POLN, NCLN, NCL | PDK1 3624/4885CYP19A1 1594/4885ALDH1A1 525/4885 |
| US-20220234989-A1 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME | DNPEP, NQO1, DNPH1 | PDK1 145/4885CYP19A1 619/4885ALDH1A1 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.