Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1535501 | 0.82 | RGS4 (0.58) | RGS4GAABACE1ALDH1A1MAPT | |
| SCHEMBL15355922 | 0.77 | RGS4 (0.41) | RGS4GAABACE1ALDH1A1MAPT | |
| SCHEMBL11000239 | 0.76 | RGS4 (0.44) | RGS4GAAALDH1A1MAPTNPSR1 | |
| SCHEMBL28976871 | 0.72 | MTOR (0.43) | RGS4CNR1BACE1 | |
| SCHEMBL16456162 | 0.71 | SENP1 (0.39) | CNR1GPR55ALDH1A1MAPTNPSR1 | |
| SCHEMBL1010796 | 0.71 | ALDH1A1 (0.46) | CNR1GPR55ALDH1A1MAPTNPSR1 | |
| SCHEMBL7857789 | 0.68 | RGS4 (0.54) | RGS4GAABACE1PTPN1ALDH1A1 | |
| SCHEMBL8568475 | 0.68 | RGS4 (0.43) | RGS4GAAALDH1A1MAPTNPSR1 | |
| SCHEMBL3470129 | 0.67 | RGS4 (0.53) | RGS4CNR1ALDH1A1MAPTNPSR1 | |
| SCHEMBL6878003 | 0.67 | RGS4 (0.57) | RGS4GAABACE1PTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040038876-A1 | Polymer conjugates of hedgehog proteins and uses | CURIS, INC. | 2004-02-26 | — | — | US | disclosed |
| EP-1183271-A1 | POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES | BIOGEN, INC. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000073337-A9 | POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES | BIOGEN INC (US) | 2002-02-14 | — | — | WO | disclosed |
| WO-2000073337-A1 | POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES | BIOGEN, INC. (US) | 2000-12-07 | — | — | WO | disclosed |