Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814148 | 0.86 | LOXL2 (0.40) | TRPA1EPHX2MMP13 | |
| SCHEMBL6476858 | 0.84 | TRPA1 (0.49) | TRPA1CHRM4MAPT | |
| SCHEMBL6819192 | 0.83 | MMP13 (0.41) | TRPA1EPHX2MMP13MAPK1SCD | |
| SCHEMBL6814142 | 0.82 | KDM5A (0.35) | TRPA1SCDMAPT | |
| SCHEMBL5957404 | 0.79 | TRPA1 (0.80) | TRPA1EPHX2MMP13PDE10A | |
| SCHEMBL6484565 | 0.77 | RXRA (0.35) | TRPA1CHRM4MAPK1SCDMAPT | |
| SCHEMBL5957431 | 0.72 | TRPA1 (0.79) | TRPA1EPHX2MMP13MAPK1 | |
| SCHEMBL5957665 | 0.72 | TRPA1 (0.76) | TRPA1EPHX2MMP13MAPK1 | |
| SCHEMBL5957671 | 0.72 | TRPA1 (0.76) | TRPA1EPHX2MMP13CHRM4 | |
| SCHEMBL5957646 | 0.72 | TRPA1 (0.79) | TRPA1EPHX2MMP13MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014908-A1 | HETEROBICYLCIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |