Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 6/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814148 | 0.90 | LOXL2 (0.40) | KDM5AKDM5BTRPA1KDM4CGRM2 | |
| SCHEMBL6819189 | 0.85 | KDM5A (0.37) | KDM5AKDM5BKDM4CFYNSTING1 | |
| SCHEMBL6484565 | 0.84 | RXRA (0.35) | KDM5AKDM5BTRPA1SCDMAPT | |
| SCHEMBL6814145 | 0.82 | TRPA1 (0.52) | TRPA1SCDMAPT | |
| SCHEMBL6819195 | 0.75 | LOXL2 (0.40) | KDM5AKDM5BTRPA1KDM4CGRM2 | |
| SCHEMBL6476858 | 0.71 | TRPA1 (0.49) | TRPA1MAPT | |
| SCHEMBL6819192 | 0.70 | MMP13 (0.41) | TRPA1SCD | |
| SCHEMBL6485426 | 0.69 | P2RY14 (0.36) | KDM5AKDM5BFYNSCDP2RY14 | |
| Niacinamide SCHEMBL6818598 | 0.69 | FYN (0.39) | FYNMAPTP2RY14 | |
| SCHEMBL6476888 | 0.66 | RXRA (0.35) | KDM5AKDM5BKDM4CP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014908-A1 | HETEROBICYLCIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |